Publications by authors named "Olivier Nerriere"
The skin is the first protective barrier of our body. Wound healing is therefore an essential mechanism. However, this phenomenon can be impaired when wounds are too large or chronic, for example, in diabetes.
View Article and Find Full Text PDFBackground: Wound repair is one of the most complex biological processes of human life. Allogeneic cell-based engineered skin substitutes provide off-the-shelf temporary wound coverage and act as biologically active dressings, releasing growth factors, cytokines and extracellular matrix components essential for proper wound healing. However, they are susceptible to immune rejection and this is their major weakness.
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- Monoclonal antibodies (mAbs) are rapidly growing in popularity as therapeutic proteins, prompting the need for more efficient manufacturing processes.
- Researchers have found that the EB66 cell line, derived from duck embryonic stem cells, can produce mAbs at high yields (over 1 g/L) in serum-free conditions.
- This cell line also exhibits favorable growth properties, such as a short doubling time and low waste accumulation, while its mAbs have reduced fucose content which enhances their effectiveness in immune responses.