Early Detection of Localized Immunity in Experimental Autoimmune Myocarditis Using [Tc]Fucoidan SPECT.

Purpose: The aim of the study was to evaluate the ability of technetium-99m-fucoidan ([Tc]fucoidan), a molecular imaging agent specific for selectins, in the assessment of early localized immunity in a rat model of experimental autoimmune myocarditis (EAM).

Procedures: EAM was induced in Lewis rats and troponin T; brain natriuretic peptide (BNP) and anti-myosin antibodies were measured in plasma. Separately, [Tc]fucoidan single-photon emission computed tomography (SPECT)/x-ray computed tomography (CT) was performed in the very early phase of myocarditis at 10, 15, and 21 days after immunization.

Preclinical validation of 99mTc-annexin A5-128 in experimental autoimmune myocarditis and infective endocarditis: comparison with 99mTc-HYNIC-annexin A5.

Hydrazinonicotinamide-annexin A5 (HYNIC-Anx), a 99m technetium (99mTc)-labeled agent targeting phosphatidylserine, proved to be sensitive for the detection of apoptosis and thrombosis but is no longer available for clinical use. A mutant of human annexin designed for direct 99mTc labeling (referred to as Anx A5-128) showed improved binding affinity to phosphatidylserine and is expected to be used in humans. We compared both radiotracers with regard to pharmacokinetics and diagnostic ability in animal models.

Mesalamine-induced myocarditis.

Nowadays mesalamine is a common treatment for Crohn's disease and hypersensitive reactions to this product have been reported. Yet there is limited information concerning mesalamine-induced myocarditis and its mechanism is not known. We described a case of mesalamine-induced myocarditis in Crohn's disease of the colon.

Cannabis induced acute coronary syndrome in a young female.

Nowadays cannabis is the most common substance of drug abuse and pathophysiological effects have been described on the cardiovascular system. Yet there is limited information concerning cannabis induced acute coronary syndrome and the exact contribution of cannabis smoking to coronary artery disease and its mechanism are not known. We describe a case of acute coronary syndrome following cannabis smoking in a young female with no predisposing causes for thrombosis.