Whistleblowing legislation and reporting on research misconduct: A case for mutual learning.

Regulations on reporting research misconduct have undergone a remarkable process of development since the 1980s. At the same time, many states have also developed legislation governing the receiving of alerts and for protecting whistleblowers against reprisal. Although these two bodies of legislation share the aim of organizing the practice of reporting, they have been developed in isolation from each other, and without sufficient thought as to how they should be linked.

Sniff nasal inspiratory pressure in the longitudinal assessment of young Duchenne muscular dystrophy children.

Traditional measures of respiratory function in children with Duchenne muscular dystrophy (DMD) are based on maximal inspiratory pressure (PImax) and vital capacity (VC). Sniff nasal inspiratory pressure (SNIP) measurements are easily performed by young children with neuromuscular disorders. The clinical value of SNIP in the longitudinal assessment of respiratory weakness remains to be assessed.

Oxidative stress is an important component of airway inflammation in mice exposed to cigarette smoke or lipopolysaccharide.

1. It was proposed previously that oxidative stress is a main component of the inflammatory process in chronic obstructive pulmonary disease (COPD). Thus, in the present study, we investigated the inflammatory response in mice deficient for the p47(phox) subunit of NADPH oxidase (p47 KO) exposed to cigarette smoke (CS).

The absence of reactive oxygen species production protects mice against bleomycin-induced pulmonary fibrosis.

Background: Reactive oxygen species and tissue remodeling regulators, such as metalloproteinases (MMPs) and their inhibitors (TIMPs), are thought to be involved in the development of pulmonary fibrosis. We investigated these factors in the fibrotic response to bleomycin of p47phox -/- (KO) mice, deficient for ROS production through the NADPH-oxidase pathway.

Methods: Mice are administered by intranasal instillation of 0.