Optimized Virtual Sources Distributions for 3-D Ultrafast Diverging Wave Compounding Imaging: A Simulation Study.

Ultrafast ultrasound imaging allows observing rapid phenomena; combined with 3-D imaging it has the potential to provide a more accurate analysis of organs which leads, in the end, to better diagnosis. Coherent compounding using diverging waves is commonly used to reconstruct high-quality images on large volumes while keeping the frame rate high enough to allow dynamic analysis. In practice, the virtual sources (VSs) that drive the diverging waves are often distributed in a deterministic way: following a regular grid, concentric rings, and spirals.

Regularization-Based 2D Strain Tensor Imaging in Quasi-Static Ultrasound Elastography .

Accurately estimating all strain components in quasi-static ultrasound elastography is crucial for the full analysis of biological media. In this study, 2D strain tensor imaging was investigated, focusing on the use of a regularization method to improve strain images. This method enforces the tissue property of (quasi-) incompressibility, while penalizing strong field variations, to smooth the displacement fields and reduce the noise in the strain components.

2D tissue strain tensor imaging in quasi-static ultrasound elastography.

Accurately estimating all strain components in quasi-static ultrasound elastography is crucial for the full analysis of biological media. In this paper, 2D strain tensor imaging is investigated, using a partial differential equation (PDE)-based regularization method. More specifically, this method employs the tissue property of incompressibility to smooth the displacement fields and reduce the noise in the strain components.

Spectral Doppler Measurements With 2-D Sparse Arrays.

The 2-D sparse arrays, in which a few hundreds of elements are distributed on the probe surface according to an optimization procedure, represent an alternative to full 2-D arrays, including thousands of elements usually organized in a grid. Sparse arrays have already been used in B-mode imaging tests, but their application to Doppler investigations has not been reported yet. Since the sparsity of the elements influences the acoustic field, a corresponding influence on the mean frequency (Fm), bandwidth (BW), and signal-to-noise ratio (SNR) of the Doppler spectra is expected.

Quantitative assessment of media concentration using the Homodyned K distribution.

The Homodyned K distribution has been used successfully as a tool in the ultrasound characterization of sparse media, where the scatterer clustering parameter α accurately discriminates between media with different numbers of scatterers per resolution cell. However, as the number of scatterers increases and the corresponding amplitude statistics become Rician, the reliability of the α estimates decreases rapidly. In the present study, we assess the usefulness of α for the characterization of both sparse and concentrated media, using simulated independent and identically distributed (i.

Quantitative Ultrasound in Ex Vivo Fibrotic Rabbit Livers.

Liver fibrosis is the common result of chronic liver disease. Diagnosis and grading liver fibrosis for patient management is mainly based on blood tests and hepatic puncture-biopsy, which is particularly invasive. Quantitative ultrasound (QUS) techniques provide insight into tissue microstructure and are based on the frequency-based analysis of the signals from biologic tissues.

Experimental Implementation of a Pulse Compression Technique Using Coherent Plane-Wave Compounding.

The axial resolution of an ultrasound imaging system is inversely proportional to the bandwidth of the emitted signal. When conventional pulsing (CP) is used, the impulse response of the transducer and the excitation signal determine together the shape of the emitted pulse and its bandwidth. A way to increase the ultrasound image resolution is to increase the transducer's limited passband.

Radiofrequency ultrasound data acquisition with a 640-element array transducer for strain imaging: Experimental results with phantoms and biological tissue samples.

This paper presents ultrasound elastography results obtained with a 640-element array transducer we have recently developed. This probe allows the acquisition of series of three adjacent imaging planes over time and therefore makes possible the computation of 2-D elastograms, with consideration of out-of-plane motion. In this study, elastography experiments were conducted on phantoms and bovine tissue samples, and compression was manually applied to the media via the hand-held ultrasound transducer.

Specific Ultrasound Data Acquisition for Tissue Motion and Strain Estimation: Initial Results.

Ultrasound applications such as elastography can benefit from 3-D data acquisition and processing. In this article, we describe a specific ultrasound probe, designed to acquire series of three adjacent imaging planes over time. This data acquisition makes it possible to consider the out-of-plane motion that can occur at the central plane during medium scanning, and is proposed with the aim of improving the results of strain imaging.

Fast Nonlinear Ultrasound Propagation Simulation Using a Slowly Varying Envelope Approximation.

Medical systems usually consider linear propagation of ultrasound, an approximation of reality. However, numerous studies have attempted to accurately simulate the nonlinear pressure wave distortion and to evaluate the contribution of harmonic frequencies. In such simulations, the computation time is very large, except for the method based on the angular spectrum scheme where the derivative order is reduced using the Fourier transform.

Evaluation of NADPH oxidases as drug targets in a mouse model of familial amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease characterized by progressive loss of motor neurons, gliosis, neuroinflammation and oxidative stress. The aim of this study was to evaluate the involvement of NADPH oxidases (NOX) in the oxidative damage and progression of ALS neuropathology. We examined the pattern of NOX expression in spinal cords of patients and mouse models of ALS and analyzed the impact of genetic deletion of the NOX1 and 2 isoforms as well as pharmacological NOX inhibition in the SOD1(G93A) ALS mouse model.

Evaluation of a frequency-domain ultrasonic imaging attenuation compensation technique.

Ultrasound attenuation is typically compensated for in clinical scanners by using time gain compensation (TGC). However, TGC operates in a frequency-independent fashion and therefore the spatial resolution of the echographic images degrades as the examination depth increases. In the current study, the capability of a multi-band attenuation compensation (MBAC) TGC technique to recover both magnitude and spatial resolution in lossy media was evaluated.

Generalization of Multipulse Transmission Techniques for Ultrasound Imaging.

To increase the contrast-to-tissue ratio (CTR) in contrast imaging or the signal-to-noise ratio (SNR) in tissue harmonic imaging, many multipulse transmission techniques have been suggested. This article first recalls the various imaging techniques proposed in the literature and then presents a mathematical background to synthesize and generalize most of the multipulse ultrasound imaging techniques. The formulation presented can be used to predict the relative amplitude of the nonlinear components in each frequency band and to design new transmission sequences to either increase or decrease specified nonlinear components in each harmonic band.

Experimental evaluation of spectral-based quantitative ultrasound imaging using plane wave compounding.

Quantitative ultrasound (QUS) based on backscatter coefficient (BSC) estimation has shown potential for tissue characterization. Beamforming using plane wave compounding has advantages for echographic, Doppler, and elastographic imaging; however, to date, plane wave compounding has not been experimentally evaluated for the purpose of BSC estimation. In this study, two BSC-derived parameters (i.

Thomson's multitaper approach combined with coherent plane-wave compounding to reduce speckle in ultrasound imaging.

In ultrasound imaging, the speckle pattern limits the image quality. Spatial and frequency compounding are commonly used to reduce speckle noise or improve the contrast. Although recent implementations can preserve a frame rate that is compatible with real-time imaging (e.

Ultrasound contrast imaging: influence of scatterer motion in multi-pulse techniques.

In ultrasound contrast imaging, many techniques based on multiple transmissions have been proposed to increase the contrast-to-tissue ratio (CTR). They are generally based on the response of static scatterers inside the imaged region. However, scatterer motion, for example in blood vessels, has an inevitable influence on multi-pulse techniques, which can either enhance or degrade the technique involved.

CREANUIS: a non-linear radiofrequency ultrasound image simulator.

Nonlinear ultrasound methods are widely used in clinical applications for tissue or contrast harmonic imaging. Accurate non-linear imaging simulation tools are required in research studies for the development of new methods. However, in existing simulators, the possible inhomogeneity of the coefficient of non-linearity, which is generally observed in tissue and in particular when contrast agents are involved, has not yet been implemented.

Frequency-domain-based strain estimation and high-frame-rate imaging for quasi-static elastography.

In freehand elastography, quasi-static tissue compression is applied through the ultrasound probe, and the corresponding axial strain is estimated by calculating the time shift between consecutive echo signals. This calculation typically suffers from a poor signal-to-noise ratio or from the decorrelation between consecutive echoes resulting from an erroneous axial motion impressed by the operator. This paper shows that the quality of elastograms can be improved through the integration of two distinct techniques in the strain estimation procedure.

A restoration framework for ultrasonic tissue characterization.

Ultrasonic tissue characterization has become an area of intensive research. This procedure generally relies on the analysis of the unprocessed echo signal. Because the ultrasound echo is degraded by the non-ideal system point spread function, a deconvolution step could be employed to provide an estimate of the tissue response that could then be exploited for a more accurate characterization.

Fundamental and second-harmonic ultrasound field computation of inhomogeneous nonlinear medium with a generalized angular spectrum method.

The simulation of nonlinear propagation of ultrasound waves is typically based on the Kuznetsov-Zabolotskaya- Khokhlov equation. A set of simulators has been proposed in the literature but none of them takes into account a possible spatial 3-D variation of the nonlinear parameter in the investigated medium. This paper proposes a generalization of the angular spectrum method (GASM) including the spatial variation of the nonlinear parameter.

Extensions of nonlinear B/A parameter imaging methods for echo mode.

This paper investigates nonlinear B/A parameter imaging in ultrasound echo mode. First, the B/A estimation methods which can be extended to echo mode are identified. The finite amplitude approaches are found to be excellent candidates to assess the nonlinear parameter because of their experimental simplicity, supported by a strong mathematical background.

On the potential of ultrasound elastography for pressure ulcer early detection.

Purpose: Pressure ulcers are areas of soft tissue breakdown induced by a sustained mechanical stress that damages the skin and underlying tissues. They represent a considerable burden to the society in terms of health care and cost. Yet, techniques for prevention and detection of pressure ulcers still remain very limited.

Second harmonic inversion for ultrasound contrast harmonic imaging.

Ultrasound contrast agents (UCAs) are small micro-bubbles that behave nonlinearly when exposed to an ultrasound wave. This nonlinear behavior can be observed through the generated higher harmonics in a back-scattered echo. In past years several techniques have been proposed to detect or image harmonics produced by UCAs.

A compensative model for the angle-dependence of motion estimates in noninvasive vascular elastography.

Purpose: Atherosclerosis of peripheral cerebral arteries can lead to stroke either by stenosis formation or plaque rupture. This pathology is initiated by the alteration of arterial wall mechanical properties shown to be assessable by ultrasound elastography. Recently, noninvasive vascular elastography (NIVE) was introduced for noninvasive imaging of the mechanical properties of superficial arteries as markers of vulnerable plaques.

A key role for NOX4 in epithelial cell death during development of lung fibrosis.

Unlabelled: The pathogenesis of pulmonary fibrosis is linked to oxidative stress, possibly generated by the reactive oxygen species (ROS) generating NADPH oxidase NOX4. Epithelial cell death is a crucial early step in the development of the disease, followed only later by the fibrotic stage. We demonstrate that in lungs of patients with idiopathic lung fibrosis, there is strong expression of NOX4 in hyperplastic alveolar type II cells.