Implementing Standard Diagnosis and Treatment for Locally Advanced Breast Cancer Through Global Research in Latin America: Results From a Multicountry Pragmatic Trial.

Purpose: Breast cancer mortality rates in Latin America (LA) are higher than those in the United States, possibly because of advanced disease presentation, health care disparities, or unfavorable molecular subtypes. The Latin American Cancer Research Network was established to address these challenges and to promote collaborative clinical research. The Molecular Profiling of Breast Cancer Study (MPBCS) aimed to evaluate the clinical characteristics and treatment outcomes of LA participants with locally advanced breast cancer (LABC).

Thromboembolic and hemorrhagic complications in patients with prosthetic heart valves cared for in a tertiary care center. What have we learned?

Background: Heart valve replacement surgery with mechanical or biological prostheses entails a risk of thromboembolism and bleeding complications.

Objective: To determine the complications related to complementary anticoagulation therapy and the probability of risk.

Methods: One-hundred and sixty-three patients who underwent heart valve replacement between 2002 and 2016 with either mechanical or biological prostheses, and who received vitamin K antagonists after hospital discharge, were studied.

Antiproliferative activity of standardized herbal phytopreparation from .

Several studies have shown that active compounds of (cardenolides) have antiproliferative effect on human cancer cells. Cardenolides isolated from can be used as active chemical markers to elaborate phytopharmaceutical preparations. The aim of this work was to evaluate the antiproliferative effect of a standardized extract of the aerial parts, based on cardenolides.

Antiproliferative and Apoptotic Activities of the Medicinal Plant .

Background: is a spiny shrub found in Northwest Mexico desert, with traditional medicinal use to treat several diseases including cancer.

Objective: The aims of the present study were to evaluate the antiproliferative and apoptotic activities of the aerial parts of this plant.

Materials And Methods: The methanol extract and its fractions were prepared using several solvents.