Exploring clozapine use in severe psychiatric symptoms associated with autism spectrum disorder: A scoping review.

Background: Patients with autism spectrum disorder (ASD) may experience severe psychiatric symptoms, often unresponsive to conventional pharmacological therapies, highlighting the need for more effective alternatives.

Aims: This study aims to map and synthesize evidence on the use of clozapine as a therapeutic option for managing severe psychiatric symptomatology co-occurring with ASD.

Methods: We conducted a scoping review on multiple sources following the JBI guidelines.