Mitochondria are the metabolic hub of the cell, playing a central role in regulating immune responses. Dysfunction of mitochondrial reprogramming can occur during bacterial and viral infections compromising hosts' immune signaling. Comparative evaluation of these alterations in response to bacterial and viral ligands can provide insights into a cell's ability to mount pathogen-specific responses.
View Article and Find Full Text PDFSilicon photomultipliers (SiPMs) are an emerging solid-state alternative to photomultiplier tubes (PMTs) for low light detection, with similar gain but lower cost and lower operating voltage. We demonstrate coherent anti-Stokes Raman scattering (CARS) imaging in a side-by-side comparison of an uncooled SiPM with an uncooled multialkali PMT as well as a state-of-the-art cooled GaAsP PMT. We determine the optimum reverse-bias voltage for acquiring the best signal-to-noise ratio (SNR) for CARS imaging of lipids at ${2850}\;{{\rm cm}^{ - 1}}$2850cm.
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