Publications by authors named "Olivia R White"
In , avoidance behaviors are vital for the nematode's ability to respond to noxious environmental stimuli, including the odorant 1-octanol. To test avoidance to 1-octanol, researchers expose to this odorant and determine the time taken to initiate backward locomotion. However, the 1-octanol avoidance assay is sensitive to sensory adaptation, where the avoidance response is reduced due to overexposure to the odorant.
View Article and Find Full Text PDFKCNQs are voltage-gated K channels that control neuronal excitability and are mutated in epilepsy and autism spectrum disorder (ASD). KCNQs have been extensively studied in neurons, but their function in glia is unknown. Using voltage, calcium, and GABA imaging, optogenetics, and behavioral assays, we show here for the first time in Caenorhabditis elegans (C.
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- - Neonatal encephalopathy (NE) is a significant issue in infant health, often resulting from hypoxia-ischemia, which can lead to brain injuries affecting areas like the basal ganglia and thalamus.
- - In this study, ferrets were subjected to a hypoxia-ischemia/hyperoxia protocol, and researchers measured their rectal temperature one hour post-injury to see if it could indicate the extent of brain damage.
- - The findings revealed that ferrets who developed spontaneous hypothermia had worse long-term neurological outcomes, suggesting that early temperature readings might serve as an important marker for predicting injury severity in neonatal brain injury contexts.
Article Synopsis
- Perinatal hypoxic-ischemic brain injury is a leading cause of death or disability in newborns, often aggravated by inflammation, and current treatments like therapeutic hypothermia may be ineffective or unavailable.
- In a study using ferret models, researchers tested different treatments including uridine monophosphate, erythropoietin, and therapeutic hypothermia to assess their effects on motor development and brain structure following injury.
- Results indicated that erythropoietin offered significant neuroprotection while uridine and therapeutic hypothermia did not improve outcomes and, in fact, uridine seemed to worsen them.