Publications by authors named "Olivia R Mitchel"
Article Synopsis
- The study looked at patients who had heart surgery called aortic root replacement and how receiving blood transfusions affected their recovery.
- Out of 760 patients, 442 received blood transfusions during their surgery, and researchers compared their results to similar patients who didn't get transfusions.
- The results showed that those who got blood transfusions had more complications after surgery, like needing longer breathing support and extra hospital time, and they had a lower chance of survival over five years compared to those who didn't get transfusions.
The immune system and placenta have a dynamic relationship across gestation to accommodate fetal growth and development. High-resolution characterization of this maternal-fetal interface is necessary to better understand the immunology of pregnancy and its complications. We developed a single-cell framework to simultaneously immuno-phenotype circulating, endovascular, and tissue-resident cells at the maternal-fetal interface throughout gestation, discriminating maternal and fetal contributions.
View Article and Find Full Text PDFThe fetal placenta is a source of hormones and immune factors that play a vital role in maintaining pregnancy and facilitating fetal growth. Cells in this extraembryonic compartment match the chromosomal sex of the embryo itself. Sex differences have been observed in common gestational pathologies, highlighting the importance of maternal immune tolerance to the fetal compartment.
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