Prehypoxic clonidine administration improves vasomotricity of isolated rat aorta during reoxygenation.

Background And Objective: Clonidine, an alpha-2 adrenoceptor (A2A) agonist, improves posthypoxic function of several organs in humans and animal models. Mechanisms underlying these effects are not fully understood. A competent vasomotricity during reperfusion participates in the organ's recovery.