Sting mediates infection by reducing accumulation of reactive oxygen species.

The Gram-negative bacterium is the causative agent of query fever in humans and coxiellosis in livestock. infects a variety of cell types, tissues, and animal species including mammals and arthropods, but there is much left to be understood about the molecular mechanisms at play during infection in distinct species. Human stimulator of interferon genes (STING) induces an innate immune response through the induction of type I interferons (IFNs), and IFN promotes or suppresses replication, depending on tissue type.