Publications by authors named "Olivia Lira-Lara"
Association of Smoking with Disease Progression in Persons with Multiple Sclerosis Undergoing Autologous Hematopoietic Cell Transplantation: A Single-Center Experience.
Rev Invest Clin
November 2024
Background: Smoking remains a significant issue that increases the prevalence of multiple sclerosis (MS) and its progression to secondary progressive forms. Objectives: The goal is to identify the relationship between smoking and disease progression in MS patients who have undergone autologous hematopoietic stem cell transplantation (auto-HSCT) at the Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, Mexico. Methods: This retrospective study involved MS patients treated with auto-HSCT, followed for 12 months.
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- The study investigates the feasibility of treating Acute Promyelocytic Leukemia (APL) patients entirely on an outpatient basis, focusing on 17 patients treated over 30 years at a clinical center in Puebla.
- All patients received the same outpatient treatment regimen involving ATRA, prednisone, and adriamycin, with 15 out of 17 successfully completing treatment outside of a hospital.
- Notably, 16 of the 17 patients achieved molecular remission, and the 12-month leukemia-free survival rate was 94%, indicating that outpatient treatment could be a viable option, especially in low-resource settings.
Background: Multiple myeloma (MM) is a disease with unspecific initial symptoms which may lead into a delay in the diagnosis, seemingly increasing the risk of complications and in turn reducing the overall survival (OS).
Objective: To analyze the consequences of a delayed diagnosis of MM in both the OS and the progression-free survival (PFS) of the patients in a single center in México.
Methods: The study included patients with MM who were diagnosed at Clínica Ruiz, Puebla, México, between 1983 and 2022.
Neutrophil to lymphocyte ratio and systemic immune-inflammatory index as markers of response to autologous hematopoietic stem cell transplantation in persons with multiple sclerosis.
Int J Lab Hematol
August 2024
Introduction: Biomarkers that help to evaluate the immune system and could be useful in multiple sclerosis (MS) are the neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII). The objective of this work is to evaluate the significance of the SII index, PLR, and NLR before and after transplantation in individuals with MS who underwent autologous hematopoietic stem cell transplant (aHSCT) at a single institution.
Methods: Patients with MS who received an aHSCT between 2017 and 2022 were included in the study.