Publications by authors named "Olivia Layton"
Heterozygous truncating variants in the sarcomere protein titin (TTN) are the most common genetic cause of heart failure. To understand mechanisms that regulate abundant cardiomyocyte TTN expression we characterized highly conserved intron 1 sequences that exhibited dynamic changes in chromatin accessibility during differentiation of human cardiomyocytes from induced pluripotent stem cells (hiPSC-CMs). Homozygous deletion of these sequences in mice caused embryonic lethality while heterozygous mice demonstrated allele-specific reduction in Ttn expression.
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- Hypertrophic cardiomyopathy (HCM) involves thickening of the heart's left ventricular wall and is related to mutations in genes affecting sarcomere proteins.
- Researchers used engineered cardiac microtissues (CMTs) made of HCM-variant cardiomyocytes and healthy fibroblasts to study how these cells interact, revealing that fibroblast proliferation contributes to increased collagen and tissue stiffness.
- The study found that signals from the HCM-variant cardiomyocytes stimulate fibroblast growth, and blocking certain receptors can reduce this effect, highlighting a potential mechanism for the fibrotic changes seen in patients with HCM.
Article Synopsis
- - A 56-year-old woman presented to the emergency department with symptoms like abdominal pain, diarrhea, fever, and low blood cell counts, which led to a diagnosis of advanced endometrial carcinosarcoma with local spread and a fistula.
- - Her case highlights how the COVID-19 pandemic increased strain on emergency services, potentially causing more gynae-oncology cases to be seen in the ED rather than through regular care channels.
- - The text suggests that restoring full primary care services could alleviate pressure on emergency departments, improve early detection of gynecological cancers, enhance multidisciplinary care, and ultimately lead to better patient outcomes.
Ovarian epithelial cancer (OEC) is an often fatal disease with poor prognosis in women with high-stage disease. In contrast, ovarian low malignant potential (LMP) tumors with favorable prognosis behaves as a disease between benign and malignant tumors. The involved genes and pathways between benign-like LMP and aggressive OEC are largely unknown.
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