Latent Profiles of Impulsivity and Emotion Regulation in Children with Externalizing Disorders are Associated with Alterations in Striatocortical Connectivity.

Introduction: Children with externalizing disorders (EDs) often have difficulties with impulsivity and emotion regulation. These constructs have been associated with dysfunction in the recruitment of reward processing circuits and striatal connectivity with cortical networks. However, it is unclear to what extent co-presentations of impulsivity and emotion regulation are associated with differences in striatocortical connectivity.

Sex differences in Cingulo-Opercular activation during risky decision-making in youth with externalizing disorders.

Background: Risky decision-making deficits predict unsafe behaviors, but sex differences in decision-making are underexplored in high-risk youth with externalizing disorders. While boys with externalizing pathology are more likely to make risky decisions, it remains unclear how these patterns manifest in girls, whose brains may process risks differently. Our study investigates sex differences in risky decision-making neurobiological activation among at-risk adolescents to identify sex-specific vulnerabilities for risky behaviors.