Publications by authors named "Olivia H Reid"
Clin Cancer Res
October 2024
Article Synopsis
- The study focuses on early detection of peripheral nerve sheath tumors (PNST) associated with neurofibromatosis type 1 (NF1) using a cell-free DNA (cfDNA) fragmentomic approach, which can improve clinical decision-making and treatment outcomes.
- Researchers isolated cfDNA from plasma samples of 101 NF1 patients and 21 healthy controls, employing whole-genome sequencing and analyzing various fragmentomic signatures to differentiate between benign, premalignant, and malignant tumors.
- Results showed that fragmentomic methods successfully distinguished atypical neurofibromas (premalignant) from benign forms and malignant PNST, offering potential for non-invasive diagnostics and better management of NF1-related tumors.*
Article Synopsis
- Early detection of neurofibromatosis type 1 (NF1) associated tumors can improve clinical decision-making and potentially reduce severe outcomes.
- A new study employed a cell-free DNA (cfDNA) fragmentomic method, successfully differentiating between benign, pre-malignant, and malignant peripheral nerve sheath tumors (PNST) in NF1 patients.
- This innovative approach allows non-invasive diagnosis and could significantly enhance the management of NF1-associated tumors, helping to differentiate conditions like atypical neurofibromas from more severe malignancies.
