Publications by authors named "Olivia G Dobbs"
Article Synopsis
- CIZ1 is a protein that stabilizes epigenetic states, particularly in the inactive X chromosome of females, and its deletion in mice leads to hyperproliferation, indicating a link to various cancers.
- In CIZ1-null murine fibroblasts, there is reduced H4K20me1, resulting in compromised nuclear condensation when entering a resting state, affecting genes related to DNA repair despite overall transcriptional repression being maintained.
- The study highlights the critical role of CIZ1 in maintaining chromatin structure during quiescence cycles, with its absence leading to genome instability, making cells more vulnerable to damage and potential transformation into cancerous colonies.
Chromatin Dynamics During Entry to Quiescence and Compromised Functionality in Cancer Cells.
Results Probl Cell Differ
November 2022
Quiescence is a vital cellular state where cells can reversibly exit the cell cycle and cease proliferation in unfavourable conditions. Cells can undergo multiple transitions in and out of quiescence during their lifetime, and an imbalance in this highly regulated process can promote tumorigenesis and disease. The nucleus experiences vast changes during entry to quiescence, including changes in gene expression and a reduction in size due to increased chromatin compaction.
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