Publications by authors named "Olivia Courbot"
Article Synopsis
- In brain metastasis, cancer cells use nearby blood vessels to migrate, a process called vessel co-option, but how this works is not well understood.
- Research using brain tissue models shows that the different stiffness levels between blood vessels and the surrounding brain tissue drive cancer cell movement.
- The study reveals that cancer cells adhere to the vessel's basement membrane and that both the rigidity of the vessels and the softness of the brain tissue influence how these cells migrate, shedding light on how mechanical properties affect cancer invasion.
The blueprint of the mammalian body plan is laid out during gastrulation, when a trilaminar embryo is formed. This process entails a burst of proliferation, the ingression of embryonic epiblast cells at the primitive streak, and their priming toward primitive streak fates. How these different events are coordinated remains unknown.
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