Publications by authors named "Olivia Ben-Levy"
Article Synopsis
- Intraductal Papillary Mucinous Neoplasms (IPMNs) are identified as precursors to pancreatic cancer, and this study explores their connection to pyloric markers and their molecular drivers.
- The research involved analyzing RNA sequencing data from IPMNs and validating findings through immunostaining in patient samples, revealing that certain oncogenes influence the expression of pyloric markers.
- Key transcription factors such as SPDEF were identified as playing a crucial role in driving the mucinous characteristics of IPMNs, indicating a potential link between these lesions and gastric epithelial changes.
Background & Aims: Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was to define the populations arising from ADM, the associated transcriptional changes, and markers of disease progression.
Methods: Acinar cells were lineage-traced with enhanced yellow fluorescent protein (EYFP) to follow their fate post-injury.