Publications by authors named "Olivia Bauvin"
In Situ Patch Test and Repeated Open Application Test for Fixed Drug Eruption: A Multicenter Study.
J Allergy Clin Immunol Pract
February 2024
Background: Few studies have evaluated allergy workup in fixed drug eruption (FDE) in a large population.
Objective: To evaluate the sensitivity of a standardized allergy workup for diagnosing the cause of FDE, with a focus on in situ repeated open application tests (ROATs).
Methods: In a retrospective multicenter study, we analyzed the practice of conducting a complete allergy workup for the etiological diagnosis of FDE.
Immune checkpoint inhibitors (ICIs) have become the standard treatment for many types of cancer. After several years of using these therapies, many adverse events related to ICIs have been observed. Dermatologic toxicities such as nonspecific morbilliform rash, vitiligo, Stevens-Johnson syndrome/toxic epidermal necrolysis, and more rarely, lichenoid eruptions have been described in the literature.
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- - This study analyzed severe blistering skin reactions caused by immune checkpoint inhibitors (ICI) in 32 patients, emphasizing that such reactions, although rare, can be life-threatening and are often misdiagnosed as epidermal necrolysis (EN).
- - The research found that symptoms like fever, ocular involvement, and extensive skin detachment were more common in patients diagnosed with EN compared to those with lichenoid dermatosis (LD) or unclassified dermatosis (UD), highlighting the need for careful diagnostic review.
- - Treatment usually involved corticosteroids, and 25% of patients died during the acute phase; however, most did not restart the ICI, suggesting a potential issue with management approaches that need further consensus and clarity
HHV-6B is the subtype most often involved in the systemic manifestations of the DRESS, but also in myelosuppression in bone marrow transplant. We report a new observation of its myelosuppressive effect: a case of DRESS complicated by agranulocytosis with detectable HHV-6 RNA in bone marrow.
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