Background: Flickering light has been shown to sensitize the migraine visual system at high stimulus contrast while elevating thresholds at low contrast. The present study employs a dichoptic psychophysical paradigm to ask whether the abnormal adaptation to flicker in migraine occurs before or after the binocular combination of inputs from the two eyes in the visual cortex.
Methods: Following adaptation to high contrast flicker presented to one eye only, flicker contrast increment thresholds were measured in each eye separately using dichoptic viewing.
Aims: Flickering light is strongly aversive to many individuals with migraine. This study was designed to evaluate other abnormalities in the processing of temporally modulating visual stimulation.
Methods: We measured psychophysical thresholds for detection of a flickering target and for the discrimination of suprathreshold flicker contrasts (increment thresholds) in 14 migraineurs and 14 healthy controls with and without prior adaptation to high-contrast flicker.