Publications by authors named "Oliver Schuetz"
Article Synopsis
- Ciprofloxacin is an antibiotic that is removed from the body by being emptied out through the kidneys and intestines.
- Scientists used special imaging (PET scans) to study how certain proteins affect how ciprofloxacin is cleared from the body in mice.
- Their findings suggest that multiple transporters help in getting rid of ciprofloxacin, which means there could be other ways the body manages this antibiotic that scientists didn't expect.
Purpose: Multidrug resistance-associated proteins (MRPs) mediate the hepatobiliary and renal excretion of many drugs and drug conjugates. The positron emission tomography (PET) tracer 6-bromo-7-[C]methylpurine is rapidly converted in tissues by glutathione-S-transferases into its glutathione conjugate, and has been used to measure the activity of Abcc1 in the brain and the lungs of mice. Aim of this work was to investigate if the activity of MRPs in excretory organs can be measured with 6-bromo-7-[C]methylpurine.
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