Publications by authors named "Oliver Peyrony"
Background: We described the real-life epidemiology and causes of infections on the different therapy phases in patients undergoing chimeric antigen receptor (CAR) T-cells directed towards CD19+ or BCMA+ cells.
Methods: All consecutive patients receiving CAR T-cell therapy at our institution were prospectively followed-up. We performed various comparative analyses of all patients and subgroups with and without infections.
High Rate of Inappropriate Antibiotics in Patients with Hematologic Malignancies and Pseudomonas aeruginosa Bacteremia following International Guideline Recommendations.
Mariana Chumbita Pedro Puerta-Alcalde Lucrecia Yáñez Maria Angeles Cuesta Anabelle Chinea Oliver Peyrony
Microbiol Spectr
August 2023
Article Synopsis
- Pseudomonas aeruginosa bloodstream infections (BSI) in febrile neutropenic patients show a growing challenge due to increasing antibiotic resistance, complicating effective treatment based on international guidelines.
- A study involving 280 BSI cases revealed that 36% of isolated P. aeruginosa strains were resistant to recommended β-lactam antibiotics, with 21.1% classified as multidrug-resistant (MDR) and 11.4% as extensively drug-resistant (XDR).
- Inappropriate empirical antibiotic treatment (IEAT) was administered to 16.8% of patients, contributing to a 30-day mortality rate of 27.1%, highlighting an urgent need for new treatment strategies.
Article Synopsis
- The study examined the epidemiology of invasive fungal infections (IFIs) in hospitalized patients over a four-year period, finding a total of 367 diagnosed cases.
- Key risk factors included corticosteroid use (41.4%) and prior viral infection (31.3%), with the most common infections being candidemia (42.2%) and invasive aspergillosis (26.7%).
- The overall mortality rate at 12 weeks post-diagnosis was 32.2%, highlighting the need for improved awareness and aggressive treatment methods among healthcare providers, especially given the increasing occurrences of resistant fungal strains.