Fracture risk prediction in postmenopausal women with traditional and machine learning models in a nationwide, prospective cohort study in Switzerland with validation in the UK Biobank.

Fracture prediction is essential in managing patients with osteoporosis and is an integral component of many fracture prevention guidelines. We aimed to identify the most relevant clinical fracture risk factors in contemporary populations by training and validating short- and long-term fracture risk prediction models in 2 cohorts. We used traditional and machine learning survival models to predict risks of vertebral, hip, and any fractures on the basis of clinical risk factors, T-scores, and treatment history among participants in a nationwide Swiss Osteoporosis Registry (N = 5944 postmenopausal women, median follow-up of 4.

An Advanced TiAl Alloy for High-Performance Racing Applications.

Requirements and strict regulations for high-performance racing applications involve the use of new and innovative lightweight structural materials. Therefore, intermetallic γ-TiAl-based alloys enable new opportunities in the field due to their lower density compared to commonly used Ni-base superalloys. In this study, a β-solidifying TiAl alloy was examined toward its use as structural material for inlet and outlet valves.

Reduced-order models for closed-loop wake control.

We review a strategy for low- and least-order Galerkin models suitable for the design of closed-loop stabilization of wakes. These low-order models are based on a fixed set of dominant coherent structures and tend to be incurably fragile owing to two challenges. Firstly, they miss the important stabilizing effects of interactions with the base flow and stochastic fluctuations.

Shell brace for stage II posterior tibial tendon insufficiency.

Background: The nonoperative treatment of posterior tibial tendon insufficiency (PTTI) can lead to unsatisfactory functional results. Short-term results are available but the impact on the evolution of the deformity is not known. To address these problems, a new brace for the flexible Stage II deformity was developed, and midterm followup was obtained.

Supramalleolar lateral closing wedge osteotomy for the treatment of varus ankle arthrosis.

Background: Medial ankle joint pain with localized cartilage degeneration due to medial joint overload in varus malalignment of the hindfoot lends itself to treatment by lateral closing wedge supramalleolar osteotomy.

Methods: From 1998 to 2003, nine patients between the ages of 21 to 59 years were operated. The etiology of the malalignment and degeneration was posttraumatic in eight and childhood osteomyelitis in one.

The "flap-shaft" prosthesis for insensate feet with Chopart or Lisfranc amputations.

Background: The inevitable detachment of tendons and the loss of the forefoot in Chopart and Lisfranc amputations result in equinus and varus of the residual foot. In an insensate foot these deformities can lead to keratotic lesions and ulcerations. The currently available prostheses cannot safely counteract the deforming forces and the resulting complications.