Apnoea-triggered increase in fraction of inspired oxygen in preterm infants: a randomised cross-over study.

Objectives: To investigate the impact of a pre-emptive apnoea triggered oxygen response on oxygen saturation (SpO) targeting following central apnoea in preterm infants.

Design: Interventional crossover study of a 12-hour period of automated oxygen control with an apnoea response (AR) module, nested within a crossover study of a 24-hour period of automated oxygen control compared with aggregated data from two flanking 12-hour periods of manual control.

Setting: Neonatal intensive care unit PATIENTS: Preterm infants receiving non-invasive respiratory support and supplemental oxygen; median (IQR) birth gestation 27 (26-28) weeks, postnatal age 17 (12-23) days.

Automated control of oxygen titration in preterm infants on non-invasive respiratory support.

Objective: To evaluate the performance of a rapidly responsive adaptive algorithm (VDL1.1) for automated oxygen control in preterm infants with respiratory insufficiency.

Design: Interventional cross-over study of a 24-hour period of automated oxygen control compared with aggregated data from two flanking periods of manual control (12 hours each).