Publications by authors named "Oliver Frost"
Article Synopsis
- - Biomaterials, essential for bone tissue engineering, require careful selection and assessment for effective clinical use, as existing models often face challenges like high costs and ethical concerns.
- - Researchers proposed using the chick embryo chorioallantoic membrane as a model to test initial bone formation with scaffolds, specifically a fibrin-alginate-calcium phosphate (FACaP) material.
- - Initial results showed early signs of bone formation and blood vessel infiltration in the scaffolds, making FACaP a promising biomaterial for applications where heavy load-bearing isn't necessary.
Organismal aging involves the progressive decline in organ function and increased susceptibility to age-associated diseases. Regardless of its origin, cellular aging is consequently reflected at the level of organ and associated systems dysfunction. Aging of stem cell populations within the body and their decreased ability to self-renew, differentiate, and regenerate damaged tissues, is a key contributor to organismal decline.
View Article and Find Full Text PDFAt a time of unpredictable challenges for health, one trend is certain: there is an exceedingly high demand for functional implants, particularly bone grafts. This has encouraged the emergence of bone tissue engineering substitutes as an alternative method to conventional bone grafts. However, the current approaches in the field face several limitations that have prevented the ultimate translation into clinical settings.
View Article and Find Full Text PDFControl of cell-surface interaction is necessary for biomaterial applications such as cell sheets, intelligent cell culture surfaces, or functional coatings. In this paper, we propose the emergent property of cell morphology as a design parameter in the bioengineering of cell-biomaterial surface interactions. Cell morphology measured through various parameters can indicate ideal candidates for these various applications thus reducing the time taken for the screening and development process.
View Article and Find Full Text PDFArticle Synopsis
- Researchers aimed to create new composite biomaterials with properties that promote blood vessel formation and bone growth for use in tissue engineering, addressing issues with traditional bone autografts.
- They developed a porous fibrin/alginate scaffold with calcium phosphate incorporated, which demonstrated favorable characteristics for bone cell attachment, growth, and differentiation.
- The scaffolds also showed positive results in promoting blood vessel formation and were biocompatible, indicating potential for further development in clinical applications.