Publications by authors named "Oliver Chinot"
Article Synopsis
- A study evaluated the effectiveness and safety of bevacizumab (BEV) for patients with recurrent glioblastoma who had already undergone first-line treatment with radiotherapy and temozolomide.
- The TAMIGA trial involved randomizing patients after they experienced disease progression into two groups: one receiving lomustine (CCNU) with BEV and the other receiving CCNU with a placebo.
- Results indicated that the trial was halted due to high dropout rates, with median survival slightly better in the CCNU + BEV group (6.4 months) compared to the CCNU + placebo group (5.5 months), but the difference was not statistically significant.
Purpose Of Review: A major recent clinical research focus for glioblastoma has been the therapeutic evaluation of antiangiogenic agents. Several vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitors and a soluble decoy VEGF receptor have demonstrated nominal benefit among patients. In contrast, bevacizumab, a humanized VEGF monoclonal antibody, exhibits evidence of apparent antitumor benefit, although these data remain controversial.
View Article and Find Full Text PDFObjective: To investigate the respective role of fractionated radiotherapy (FR) and gamma knife stereotactic (GKS) radiosurgery in cavernous sinus meningioma (CSM) treatment.
Methods: The authors report the long-term follow-up of two populations of patients harboring CSMs treated either by FR (Group I, 38 patients) or GKS radiosurgery (Group II, 36 patients). There were 31 females with a mean age of 53 years in Group I and 29 females with a mean age of 51.
Glioblastoma multiforme is the most malignant of the primary brain tumors and is almost always fatal. The treatment strategies for this disease have not changed appreciably for many years and most are based on a limited understanding of the biology of the disease. Growth factors are potential targets for therapeutic strategies because they are essential for tumor growth and progression.
View Article and Find Full Text PDF