Increased phage resistance through lysogenic conversion accompanying emergence of monophasic Typhimurium ST34 pandemic strain.

serovar Typhimurium (. Typhimurium) comprises a group of closely related human and animal pathogens that account for a large proportion of all infections globally. The epidemiological record of .

Delineating the impact of COVID-19 on antimicrobial resistance: An Indian perspective.

The COVID-19 pandemic has shattered millions of lives globally and continues to be a challenge to public health due to the emergence of variants of concern. Fear of secondary infections following COVID-19 has led to an escalation in antimicrobial use during the pandemic, while some antimicrobials have been repurposed as treatments for SARS-CoV-2, further driving antimicrobial resistance. India is one of the largest producers and consumers of antimicrobials globally, hence the task of curbing antimicrobial resistance is a huge challenge.

A integrative and conjugative element with a CRISPR-Cas9 system targeting competing plasmids: a history of plasmid warfare?

Microbial genomes are highly adaptable, with mobile genetic elements (MGEs) such as integrative conjugative elements (ICEs) mediating the dissemination of new genetic information throughout bacterial populations. This is countered by defence mechanisms such as CRISPR-Cas systems, which limit invading MGEs by sequence-specific targeting. Here we report the distribution of the pVir, pTet and PCC42 plasmids and a new 70–129 kb ICE (CampyICE1) in the foodborne bacterial pathogens and .

Whole-genome epidemiology links phage-mediated acquisition of a virulence gene to the clonal expansion of a pandemic serovar Typhimurium clone.

Epidemic and pandemic clones of bacterial pathogens with distinct characteristics continually emerge, replacing those previously dominant through mechanisms that remain poorly characterized. Here, whole-genome-sequencing-powered epidemiology linked horizontal transfer of a virulence gene, , to the emergence and clonal expansion of a new epidemic serovar Typhimurium (. Typhimurium) clone.

SGI-4 in Monophasic Typhimurium ST34 Is a Novel ICE That Enhances Resistance to Copper.

A multi drug resistant 4,[5],12:i- of sequence type 34 (monophasic . Typhimurium ST34) is a current pandemic clone associated with livestock, particularly pigs, and numerous outbreaks in the human population. A large genomic island, termed SGI-4, is present in the monophasic Typhimurium ST34 clade and absent from other .