Taxonomic and molecular characterization of sp. nov. (Digenea, Fellodistomidae), a parasite of Günther, 1878 (Gadiformes, Macrouridae) from the deep sea southeastern Pacific Ocean.

a new species of deep-sea digenean, parasitizing the gallbladder of the "Bigeye grenadier" ( Günther, 1878) in the deep waters of the southeastern Pacific Ocean is described on the basis of morphological and molecular (28S rRNA) data. The new species is distinguishable from Yamaguti, 1940, the only other member of the genus, by its subterminal oral sucker, the position of the ovary and testes, the larger anterior seminal vesicle compared to the posterior one, and its larger eggs. In addition, the new species is a parasite of a deep-sea fish, whereas is a parasite of shallow-water fish.

Lavender Essential Oil and Its Terpenic Components Negatively Affect Tumor Properties in a Cell Model of Glioblastoma.

Glioblastoma (GBM) is the most common and aggressive form of brain cancer in adults, characterized by extensive growth, a high recurrence rate, and resistance to treatment. Growing research interest is focusing on the biological roles of natural compounds due to their potential beneficial effects on health. Our research aimed to investigate the effects of lavender essential oil (LEO) on a GBM cell model.

High Arctic lakes reveal accelerating ecological shifts linked to twenty-first century warming.

The Arctic is among the most rapidly warming regions on Earth, and climate change has triggered widespread alterations to its cryosphere and ecosystems. Among these, high Arctic lakes are highly sensitive to rising temperatures due to the influence of ice cover on multiple limnological processes. Here, we studied the sediments of three lakes on northern Ellesmere Island (82.

Nutritional characterization of patients with oropharyngeal cancers: impact of human papillomavirus status.

Background: Oropharyngeal squamous cell carcinoma (OPSCC) of human papillomavirus (HPV)-positive status is increasing relative to HPV-negative disease. Nutritional features of OPSCC patients according to HPV status is unclear.

Subjects/methods: Canadian and Spanish patients with OPSCC were assessed for body mass index (BMI), weight loss grade (WLG), and computed tomography-defined skeletal muscle index (SMI).

Differential DNA methylation in the benign and cancerous prostate tissue of African American and European American men.

Background: African American (AA) men are at increased risk of prostate cancer (PCa) compared to men of European ancestry (EA). Biological mechanisms, including epigenetics, likely contribute to this disparity, but prior studies have been limited by sample size, candidate gene approaches, or lack of epigenome-wide DNA methylation (DNAm) data.

Methods: To improve our understanding of these mechanisms, we compared DNAm features distinguishing tumor and paired histologically benign tissue from 76 AA and 75 EA PCa patients.

Effect of Distress, Anxiety, and Depressive Symptoms on SARS-CoV-2 mRNA BNT162b2 Vaccine Efficacy in Cancer Patients.

Background/objectives: Our previous study of 291 cancer patients, we showed that 20% did not respond to two doses of COVID-19 vaccine administered six weeks apart.

Methods: Here, we investigated if psychological factors (distress, anxiety, and depressive symptoms) affected antibody response and markers of vaccine activation (D-dimer) after 6 months from initial vaccination.

Results: Overall, 31 subjects (14.

Short alkyl-chained Imidazolium-based Ionic Liquids: Promising green solution or potential environmental threat?

Ionic Liquids (ILs) are currently applied in a wide variety of fields, with promising outcomes in microalgae high value biocompounds extraction. The occurrence of these compounds in natural water systems, with their characteristic stability and low biodegradability, becomes a threat worthy of attention. In the present study, Dunaliella tertiolecta, Isochrysis galbana and Rhinomonas reticulata were exposed to 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([BMIM] TfN) for 72, 168 and 264 h, at 20 and 25 °C.

Pharmacological Blockade of Group II Metabotropic Glutamate Receptors Reduces the Incidence of Brain Tumors Induced by Prenatal Exposure to N-ethyl-N-nitrosourea in Rats.

Background: The study demonstrates that pharmacological blockade of type 3 metabotropic glutamate (mGlu3) receptors at the time of tumor induction significantly reduces the incidence of brain gliomas in rats. The overall survival of patients with high-grade brain gliomas is 14-20 months after current multimodal therapy, including surgery, radiotherapy, and adjuvant chemotherapy.

Objective: To demonstrate in this experimental model that pharmacological blockade of group II metabotropic glutamate receptors reduces the incidence of brain tumors induced by prenatal exposure to N- ethyl-N-nitrosourea (ENU) in rats.

Enhanced warming of European mountain permafrost in the early 21st century.

Mountain permafrost, constituting 30% of the global permafrost area, is sensitive to climate change and strongly impacts mountain ecosystems and communities. This study examines 21st century permafrost warming in European mountains using decadal ground temperature data from sixty-four boreholes in the Alps, Scandinavia, Iceland, Sierra Nevada and Svalbard. During 2013-2022, warming rates at 10 metres depth exceed 1 °C dec in cases, generally surpassing previous estimates because of accelerated warming and the use of a comprehensive data set.

Salvage chemotherapy after progression on immunotherapy in recurrent/metastatic squamous cell head and neck carcinoma.

Objectives: Anti-PD-(L)1 agents changed the landscape of recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) treatment. Previous studies showed improved response rates to salvage chemotherapy (SCT) after progression to anti-PD-(L)1 agents. This study aims to evaluate the outcomes of SCT and to identify predictors of response and survival in patients with R/M HNSCC.

Swallowing function in patients with spinal muscular atrophy before and after the introduction of new gene-based therapies: what has changed?

Objective: Individuals diagnosed with Spinal Muscular Atrophy (SMA), particularly those presenting with the most severe phenotypes, have long contended with significant swallowing dysfunction. The recent emergence of efficacious advanced therapy has fundamentally altered the landscape of SMA management. By encompassing both the pre and post gene-based therapy eras within our analysis, we endeavour to elucidate the potential impact of these novel therapeutic interventions on this function.

The Effect of Vitamin D Supplementation Post COVID-19 Infection and Related Outcomes: A Systematic Review and Meta-Analysis.

Background: Vitamin D's role in COVID-19 management remains controversial. This meta-analysis aimed to evaluate the efficacy of vitamin D supplementation in patients with SARS-CoV-2 infection, focusing on mortality, intensive care unit (ICU) admissions, intubation rates, and hospital length of stay (LOS).

Methods: A systematic review of PubMed/MEDLINE, Scopus, Cochrane, and Google Scholar databases was conducted.

Medical Genetics for the Undiagnosed and Rare Patient: "Chasing Zebras".

The world of genetic testing continues to evolve as new technologies provide insight into previously unchartered territories. Access to genetic testing, especially for complex medical patients, could potentially improve the lives of thousands of individuals with undiagnosed conditions. Barriers to testing include financial and physical limitations, along with the emotional and social fortitude that is at times needed for vulnerable populations to agree to testing and participation in research.

Iron deficiency anemia in pregnancy and the postpartum: a practical approach by the Italian GOAL Working Group.

Background: Iron deficiency and iron deficiency anemia represent global health issues, particularly during pregnancy and the postpartum. The present paper aims to summarize the appropriate management of these conditions in order to try to improve how clinicians perceive, diagnose and treat iron deficiency and iron deficiency anemia.

Methods: An expert panel of Italian obstetricians of Lazio region was convened to evaluate the available literature on iron deficiency and iron deficiency anemia during pregnancy and the post-partum in order to try to define a flow chart on the appropriate management of such conditions; aspects related to the patient blood management have also been investigated.

Update on Inherited Pediatric Motor Neuron Diseases: Clinical Features and Outcome.

Background: Inherited pediatric motor neuron diseases (MNDs) are a group of neurodegenerative disorders characterized by the degeneration of motor neurons in the brain and the spinal cord. These diseases can manifest as early as infancy and originate from inherited pathogenic mutations in known genes. Key clinical features of MNDs include muscle weakness, hypotonia, and atrophy due to the degeneration of lower motor neurons or spasticity, hypertonia, and hyperreflexia caused by upper motor neuron dysfunction.

The TELCoMB Protocol for High-Sensitivity Detection of ARG-MGE Colocalizations in Complex Microbial Communities.

Understanding the genetic basis of antimicrobial resistance is crucial for developing effective mitigation strategies. One necessary step is to identify the antimicrobial resistance genes (ARGs) within a microbial population, referred to as the resistome, as well as the mobile genetic elements (MGEs) harboring ARGs. Although shotgun metagenomics has been successful in detecting ARGs and MGEs within a microbiome, it is limited by low sensitivity.

Establishment of single-cell transcriptional states during seed germination.

Germination involves highly dynamic transcriptional programs as the cells of seeds reactivate and express the functions necessary for establishment in the environment. Individual cell types have distinct roles within the embryo, so must therefore have cell type-specific gene expression and gene regulatory networks. We can better understand how the functions of different cell types are established and contribute to the embryo by determining how cell type-specific transcription begins and changes through germination.

High-throughput sequencing yields the complete plastid genome of the endemic species (Orchidaceae) from northeastern Peru.

is a species of orchid endemic to the Amazonas and San Martín regions. Unfortunately, its excessive extraction has made it a critically endangered species. In this study, we performed next-generation sequencing of (GenBank accession number OR348669) and assembled its complete chloroplast genome.