Ganglioglioma with glioblastoma component.

Ganglioglioma with a glioblastomatous component and high-grade atypia of neuronal cells are extremely rare findings. In this paper, we report the case of a 60-year-old man who presented with a tumor of the left temporal lobe. Hematoxylin-Eosin stained slides revealed a complex tumor with features of glioblastoma and marked atypia of neuronal cells.

Spermatic cord mixed liposarcoma. Case report and review of the literature.

A 75-years-old man presented with a clinical diagnosis of hydrocele. Grossly examination revealed a large (14x8x9 cm) tumor. Histologically, the tumor had a mixed pattern, with major pleomorphic and a minor sclerosing well-differentiated component.

Anorectal melanoma. Case report and review of the literature.

We report a case of primary anorectal melanoma, a very rare malignant tumor in this localization. The patient, a 57-year-old female, complained for one year of symptoms, which were attributed to hemorrhoids. An abdomino-perineal resection was performed.

Vaginal superficial myofibroblastoma. Case report and review of the literature.

Superficial myofibroblastoma of the lower female genital tract is a rare, recently described tumor, which has a distinctive clinico-pathological profile. We report a 63-year old patient who presented with a polypoid vaginal mass. Histopathological examination revealed a moderately cellular tumor composed of bland spindled and stellate cells.

Collision adenocarcinoma--carcinoid tumor of the colon. Case report and review of the literature.

Collision tumors are extremely rare and raise interesting problems related to histogenesis. In this paper we report a case of collision tumor of the colon and review the literature related to this subject.

Primary chondroblastic osteosarcoma of the breast. Case report and review of the literature.

Primary osteosarcomas of the breast are rare tumors. We report a 58-year-old woman who presented with a left breast lump suggestive of phyllodes tumor. A sectorectomy was performed and histological examination revealed a chondroblastic osteosarcoma, an unusual finding.

Retroperitoneal synovial sarcoma.

Retroperitoneal synovial sarcomas are very rare. The authors describe a 39-year-old male with a primary retroperitoneal synovial sarcoma showing a monophasic pattern. Immunohistochemically, the tumor cells were positive for cytokeratin AE1/AE3, epithelial membrane antigen, vimentin, S-100 protein, CD99 and calretinin.

Primary intraabdominal synovial sarcoma: a case report.

The authors report a case of intra-abdominal synovial sarcoma in a 41-year-old female. The tumor, which had an unusual location, the ascending mesocolon, had a mono-phasic spindle cell pattern. Immunohistochemical positivity for the epithelial membrane antigen (EMA) and cytokeratin AE1/AE3 differentiated the lesion from other spindle cell sarcomas with similar histology.

Synchronous gastric adenocarcinoma and carcinoid.

We report the rare case of a 68-year-old man who had two separate and histologically dissimilar gastric tumors: a poorly differentiated adenocarcinoma and a carcinoid. The latter tumor showed argyrophilic granules (Grimelius technique) and positivity for chromogranin A and neuron-specific enolase stains, confirming the neuroendocrine nature of the neoplasia. The literature concerning this subject is reviewed.

Heterotopic bone formation in gastric carcinoma. Case report and discussion of the literature.

Osseous metaplasia is a rare finding in the gastrointestinal tract. We report the case of a 75-year-old woman with a gastric adenocarcinoma showing heterotopic ossification with bone marrow formation. The pathogenetic theories are briefly discussed.

Computer-based image analysis of nucleoli in prostate carcinoma.

The authors have evaluated the nucleoli in 37 cases of prostatic carcinoma. The increase in Gleason's grade 1 correlated with an increase in the percentage of nucleolated nuclei. The increase in the percentage of bi- and trinucleolated nuclei was accompanied by a decrease of the uninucleated nuclei.

Carcinosarcoma (malignant mesodermal mixed tumor) or urinary bladder.

The authors report a case of carcinosarcoma (malignant mesodermal mixed tumor of the urinary bladder. We discuss the histological criteria of positive and differential diagnosis, the histogenesis, as well as their biological behavior.

Morphometric investigations on bone giant cell tumors.

The authors have studied 12 cases of bone giant cell tumors and have shown that the increase in aggressiveness is accompanied by higher values of mitotic activity and nuclear features (area, perimeter, long and short axes), which might be useful for grading the bone giant cell tumors.

Study on the nucleolar organiser regions in soft tissue liposarcoma.

The authors studied 24 cases of liposarcoma of soft tissue included in two categories: myxoid liposarcoma and pleomorphic liposarcoma. The 24 tumors were stained by Ploton's method for revealing the nucleolar organiser regions (AgNORs). AgNORs were counted in the nuclei of 100 cells/case.

Nucleolar organizer regions (AgNORs) in intraepithelial neoplasia of the uterine cervix.

The authors have studied the AgNORs counts in intraepithelial lesions of the uterine cervix. The following values were obtained (mean +/- SD AgNORs/cell): normal specimens--2.11 +/- 0.

Increasing gallstone prevalence and cholecystectomy rate in a large Romanian town. A necropsy study.

To study whether the increasing prevalence of gallstone disease noted in a 100-year interval in a large Romanian town has continued in recent years, we analyzed all necropsies (5234) performed during 10 years (1983-1992) in Cluj-Napoca. Gallstone disease (GD) was defined as the presence of stones or the absence of the gallbladder due to cholecystectomy. The results obtained were compared to those of the previous 10-year period (1973-1982).

Nucleolar organizer regions (AgNORs) in in situ and invasive components of breast cancers.

The authors have studied the nucleolar organizer regions (AgNORs) (which reflect the cell kinetic activity) in the in situ and invasive components of breast cancers. The mean number of AgNORs/nucleus was 4.18 (s.

Quantification of Grimelius reaction in neuroendocrine tumors of the lung.

The authors have studied the percent area occupied by the Grimelius-positive cells in lung neuroendocrine tumors. The highest values were noted in typical carcinoid tumors: they decreased progressively in atypical carcinoids, small "oat cell" carcinoma and large cell carcinoma. There was, however, a large dispersion of values, especially in the groups of typical and atypical carcinoid tumors.

Morphometric study of cell populations in primary breast tumors and their lymph node metastases.

The study of nuclear parameters (long and short nuclear axes, nuclear axes ratio, nuclear area) revealed differences both between the primary breast tumors and their lymph node metastases and between the lymph nodes isolated from the same axilla. The results are discussed in terms of tumor progression.

Mixed folliculo-papillary and squamous cell variant of medullary thyroid carcinoma.

A case of thyroid carcinoma with a triple medullary, folliculo-papillary and squamous differentiation is reported. Lymph node metastatic deposits showed folliculo-papillary and squamous cell areas. The problems of histogenesis are discussed.

Composite endocrine cell, typical adenocarcinoma and signet ring carcinoma of the gallbladder.

The authors report a case of composite tumor of the gallbladder which exhibited features of both adenocarcinoma (with typical areas, signet ring cells and clear cells) and endocrine cell carcinoma. The histological picture suggests the origin of both components in a common primitive cell with the capacity to differentiate to different types of metaplastic epithelium and supports the hypothesis of a sequence metaplasia--dysplasia--carcinoma.

Automated estimation of nuclear volume in brain tumors.

The comparative study of the percentage nuclear area in brain tumors by the point-counting technique and digital analysis showed a good correlation between the results obtained. The investigation suggests the possibility of using the volume corrected mitotic index to tumors with uniformly distributed cells.

Morphometric grading of laryngeal squamous cell carcinomas.

The authors have used the point counting method for the morphometric assessment of the histological aspect of laryngeal carcinoma. The results suggest that subjective histopathological grading tends to overestimate the tumor grade. The implications of these data for the prediction of prognosis and selection of therapy are briefly discussed.

DNA nuclear content of apocrine cells in fibrocystic mastopathy and breast cancer.

The DNA nuclear content of apocrine cells was studied in 5 cases of fibrocystic disease, 3 cases of invasive duct carcinoma and 3 cases of invasive lobular carcinoma. Both diploid and aneuploid values were found in each group. The possible significance of apocrine change in breast lesions is discussed.