Publications by authors named "Olha Ivashkiv"
Article Synopsis
- - Diverse cellular stresses activate heat shock factor 1 (HSF1), which helps manage protein stability and has broader roles in promoting cancer, but its effects on immune cells in tumors are not well understood.
- - Research using a model of HSF1 activation shows that heightened HSF1 activity in natural killer (NK) cells negatively affects their ability to kill tumors and produce cytokines for immune response.
- - HSF1 directly influences the expression of important factors for NK cell function, suggesting that understanding its role could improve therapies using NK cells to fight cancer and lead to better treatment combinations.
The conserved DnaA-oriC system is used to initiate replication of primary chromosomes throughout the bacterial kingdom; however, bacteria with multipartite genomes evolved distinct systems to initiate replication of secondary chromosomes. In the cholera pathogen, Vibrio cholerae, and in related species, secondary chromosome replication requires the RctB initiator protein. Here, we show that RctB consists of four domains.
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