[The analysis of association between ENPP1 K121Q polymorphism and risk factors of type 2 diabetes mellitus in ukrainian population].

Objective: Introduction: More than 100 genes have been described associations between single nucleotide polymorphisms and type 2 diabetes mellitus (T2DM). Among these candidate genes, Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1), is located on the long arm of chromosome 6 (6q23.2) and encodes for a protein which is one of the factors determining the insulin sensitivity.

[The association between enpp1 rs997509 polymorphism and type 2 diabetes mellitus development in ukrainian population].

Objective: Introduction: Genome-Wide Association Studies have identified a large number of polymorphic loci associated with type 2 diabetes mellitus (T2DM). Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) gene is one of the candidate genes which have primary importance in T2DM development. Several studies revealed the association between ENPP1 polymorphisms, including rs997509, and T2DM, obesity, insulin resistance and metabolic syndrome in different populations.

[Role of c+70g single nucleotide polymorphism of endothelin receptor a gene in the development of ischemic atherothrombotic stroke].

Introduction: Endothelial dysfunction is the basic pathogenic development mechanism of ischemic atherothrombotic stroke (IAS). One of the reasons for changes of endothelin structure and properties and its receptor can be genetic polymorphism of their genes.

Aim: Study of C+70G polymorphic variant associations of endothelin receptor A gene (EDNRA) with IAS development became the goal of research.