Exploring Natural Analgesics for Chronic Pain Management: Cannabinoids and Other Phytoconstituents.

Chronic pain lasting more than three months or persisting after normal healing is a significant global health issue. In a healthcare system, it is crucial to ensure proper chronic pain management. Traditional pharmacological and non-pharmacological pain management techniques may not fully meet the requirements of physicians regarding effectiveness and safety.

Significance of oxidative stress in liver damage of male and female rats with simulated ethanol hepatitis.

Objective: Aim: to find out the gender characteristics of oxidative mechanisms of liver damage in rats with ethanol hepatitis (EH).

Patients And Methods: Materials and Methods: The study was performed on 48 white male and female rats: 1 - control, 2 - acute EH (12,5 ml/kg of a 40% ethanol solution prepared on 5% solution of glucose for 7 days).The diene and triene conjugates (DC, TC), Schiff's bases (SB), TBA-active products (TBA-ap), activity of superoxide dismutase (SOD) and catalase (CAT) were determined in the blood serum.

The effect of cell therapy on the intensity of lipid peroxidation processes in the liver, kidneys and lungs of rats of different ages under conditions of experimental cranio-skeletal trauma.

Objective: Aim: To determine the effect of cell therapy on the intensity of lipid peroxidation processes in the liver, kidneys and lungs of rats of different ages under conditions of experimental cranio-skeletal trauma (CST).

Patients And Methods: Materials and Methods: In the experiments, 129 white male Wistar line rats of different age groups were used: immature rats aged 100-120 days and weighing 90-110 g; mature rats aged 6-8 months and weighing 180-200 g; and old rats aged 19-23 months and weighing 300-320 g. In each age group, CST was modeled under thiopental sodium anesthesia.

Sex features of the development of oxidative stress in high and low hypoxic resistancy rats, which experienced repeated stressful episodes of immobilization.

Objective: Aim: of the study was to find out the sexual characteristics of the development of oxidative stress in rats with high and low resistance to hypoxic hypoxia (HRH, LRH) during repeated stressful episodes of immobilization..

Patients And Methods: Materials and Methods: The study was performed on 96 white HRH, LRH male and female Wistar rats.

The Role of Vitamins, Magnesium, and Trace Elements in COVID-19 Treatment and Post-COVID-19 Rehabilitation: An Updated Overview.

This review summarizes the scientific knowledge concerning the impact of vitamins, magnesium, and trace elements on various mechanisms contributing to the possible treatment and prevention of COVID-19, including its delayed consequences. A search was conducted in various databases, including PubMed, Scopus, ClinicalTrials.- gov, and Web of Science.

EVALUATION OF POSTURAL BALANCE INDICATORS IN HEALTHY INDIVIDUALS.

Objective: The aim: To determine and generalize the indicators of stabilometry in healthy individuals for their further use as a control group in studies of pathologies of the musculoskeletal system.

Patients And Methods: Materials and methods: The study was conducted on a stable platform with biofeedback TYMO (Tyromotion). 30 male and female patients aged 18-25 years participated in the study.

THE PECULIARITIES OF BIOCHEMICAL AND MORPHOLOGICAL CHANGES IN THE HEART OF THE CASTRATED RATS IN THE DEVELOPMENT OF ADRENALIN DAMAGE OF HEART.

Objective: The aim of the study was to evaluate the state of oxidation processes and morphological changes in the heart of castrated rats during the development of epinephrine heart damage (EHD).

Patients And Methods: Materials and methods. The study was performed on 120 white male Wistar rats.

CYTOKINOGENESIS DISORDERS IN MECHANISMS OF THE EXPERIMENTAL PERODONTITIS DEVELOPMENT AND THEIR CORRECTION BY FLAVONOL.

Objective: The aim: Evaluation of changes in proinflammatory and anti-inflammatory units of the cytokine profile in the mechanisms of development of experimental bacterial-immune periodontitis and elucidation of the effect of flavonol quercetin on its parameters.

Patients And Methods: Materials and methods: Experimental periodontitis was caused by introducing into the tissues of the periodontal complex a mixture of microorganisms diluted with egg protein. In order to enhance the immune response, a complete Freund's adjuvant was injected into the rat's paw at the same time.