BIK and GRP78 protein expression as possible markers of response to preoperative chemotherapy and survival in breast cancer.

Objective: BIK and GRP78 have shown differential expression profiles in breast cancer (BC) tissue, in addition to its important participation in the pathophysiology of cancer. The purpose of this study was to evaluate the association of BIK and GRP78 protein expression with clinical and pathologic response to preoperative chemotherapy, recurrence, disease-free survival (DFS) and overall survival (OS), in patients with BC.

Material And Methods: Fifty-three patients who received preoperative chemotherapy where included in an observational, analytical and retrospective study to assess the BIK and GRP78 protein expression by immunohistochemistry in microarrays of BC tissue obtained before treatment.

Efecto de la frecuencia de aplicación de estrógenos locales sobre el grosor endometrial en mujeres posmenopáusicas.

Introduction: Conjugated estrogens, when used by the vaginal route for the relief of vaginal dryness and atrophy, can produce endometrial changes.

Objective: To know the effect of vaginal conjugated estrogens application frequency on endometrial thickness in postmenopausal women.

Method: Seventy postmenopausal women with vaginal dryness who received conjugated estrogen cream (0.

[Concordance between preoperative and definitive study in endometrial cancer].

Background: Some studies have been realized to know the concordance level between the preoperative and the diagnosis of endometrial cancer and it has been observed that there is a tendency to undergrade the stage of cancer in preoperative studies.

Methods: It was carried out an observational, retrolective, transversal and comparative study to establish the concordance between the preoperative and the definitive study in endometrial cancer. We revised the records of the Pathology department of the Hospital "Luis Castelazo Ayala" from January 1st, 2012, to December 31th, 2014.

[Association of ovarian tumors with CA-125].

Background: The tumor marker CA-125 is the most widely used serum marker for ovarian cancer screening. The aim of this paper was to establish the association between histopathologic result of ovarian tumors with serologic CA-125 and utility for the diagnosis of ovarian tumors at a Ginecoobstetric hospital.

Methods: An observational, retrospective, descriptive and longitudinal study, from September 1st 2010 to February 28 2013.