Publications by authors named "Olga Ya Brikunova"
Article Synopsis
- Researchers created innovative organosilicon MNPs modified with pHLIP and PEG, showing enhanced specificity and low cytotoxicity in vitro, particularly at acidic pH levels.
- The study revealed that these pHLIP-modified MNPs accumulated significantly more in tumors compared to standard PEGylated MNPs in mouse models, indicating their potential for better cancer imaging.
Article Synopsis
- The study examines how the acidic environment of tumors affects the delivery of magnetic nanoparticles (MNPs) modified with a peptide that responds to low pH levels.
- Researchers found that these pHLIP-conjugated MNPs were more effective at targeting cancer cells in acidic conditions (pH 6.4) compared to neutral (pH 7.2).
- Results indicated a correlation between the acidity of the tumor microenvironment and the accumulation of MNPs, suggesting the potential for personalized treatment strategies based on tumor pH profiles.
The method of FeO magnetic nanoparticle synthesis by co-precipitation, modification by 3-aminopropylsilane and conjugation with pH-(low)-insertion peptide (pHLIP) is reported. The characterization of nanoparticles by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, elemental and thermogravimetric analyses as well as dynamic light scattering and z-potential measurements is provided. The effect of nanoparticles on the viability of mouse and human peripheral blood mononuclear cells is tested by flow cytometry.
View Article and Find Full Text PDFArticle Synopsis
- Biological systems influence nanoparticle delivery in tumors more than the design of the nanoparticles themselves.
- The study focuses on the delivery of FeO magnetic nanoparticles (MNP-pHLIP) in human breast cancer models, revealing that their accumulation correlates with the tumor's volume.
- Findings indicate that the distribution of blood vessels within the tumor plays a crucial role in how effectively these nanoparticles can accumulate in the tumor tissue.