Publications by authors named "Olga Y Perik-Zavodskaia"
Article Synopsis
- Researchers aimed to develop a cellular model to study the effects of tumor necrosis factor (TNF) depending on the presence or absence of TNFR1 and TNFR2 receptors in cell lines.
- They created TNFR1 knockout versions of ZR-75/1 and K-562 cell lines to analyze how this absence affects receptor distribution, cell cycle, cell death, and gene expression in response to TNF.
- Findings showed that removing TNFR1 led to changes in TNFR2 distribution, influencing sensitivity to TNF and altering cell proliferation and death patterns in different ways across the two cell lines.
