Publications by authors named "Olga Y Brikunova"
Article Synopsis
- Testing various derivatives of a specific compound demonstrated significant cytotoxic activity against several cancer cell lines, especially for types like 4T1 and HepG2.
- The research revealed that the effective compounds must include both a difluorobenzoxazine fragment and a purine residue connected by a specific length linker.
- Further studies indicated that the most promising compound inhibits DNA biosynthesis, suggesting potential for developing new antitumor agents based on the identified purine conjugates.
Article Synopsis
- The surface architecture of nanoparticles, influenced by ligand modifications and protein interactions in biofluids, is essential for their cellular interactions in living organisms.
- In this study, we examined how immune cells interact with magnetic nanoparticles modified with polyethylene glycol (PEG) and peptide ligands, discovering that pHLIP modification improved their uptake by immune cells compared to cycloRGD.
- Although we didn't find notable differences in protein corona composition between the modified and unmodified nanoparticles, variations in nanoparticle uptake were observed among different individuals, highlighting the need to consider personal differences in serum during nanotherapy testing.
Article Synopsis
- Researchers created innovative organosilicon MNPs modified with pHLIP and PEG, showing enhanced specificity and low cytotoxicity in vitro, particularly at acidic pH levels.
- The study revealed that these pHLIP-modified MNPs accumulated significantly more in tumors compared to standard PEGylated MNPs in mouse models, indicating their potential for better cancer imaging.
Article Synopsis
- The study examines how the acidic environment of tumors affects the delivery of magnetic nanoparticles (MNPs) modified with a peptide that responds to low pH levels.
- Researchers found that these pHLIP-conjugated MNPs were more effective at targeting cancer cells in acidic conditions (pH 6.4) compared to neutral (pH 7.2).
- Results indicated a correlation between the acidity of the tumor microenvironment and the accumulation of MNPs, suggesting the potential for personalized treatment strategies based on tumor pH profiles.
The method of FeO magnetic nanoparticle synthesis by co-precipitation, modification by 3-aminopropylsilane and conjugation with pH-(low)-insertion peptide (pHLIP) is reported. The characterization of nanoparticles by scanning electron microscopy, transmission electron microscopy, Fourier-transform infrared spectroscopy, elemental and thermogravimetric analyses as well as dynamic light scattering and z-potential measurements is provided. The effect of nanoparticles on the viability of mouse and human peripheral blood mononuclear cells is tested by flow cytometry.
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- Biological systems influence nanoparticle delivery in tumors more than the design of the nanoparticles themselves.
- The study focuses on the delivery of FeO magnetic nanoparticles (MNP-pHLIP) in human breast cancer models, revealing that their accumulation correlates with the tumor's volume.
- Findings indicate that the distribution of blood vessels within the tumor plays a crucial role in how effectively these nanoparticles can accumulate in the tumor tissue.