Publications by authors named "Olga Wronikowska"
Article Synopsis
- Mephedrone is a novel psychoactive substance that is often abused, but the factors influencing vulnerability to its effects remain unclear.
- The study aimed to investigate how sex differences, social conditioning, and chronic mild unpredictable stress (CMUS) impact susceptibility to the drug's rewarding effects in Wistar rats.
- Results showed that while both male and female rats exhibited conditioned place preference for mephedrone, social conditioning and CMUS specifically increased the reward response, particularly with lower doses of the drug, suggesting complex interactions affecting susceptibility to mephedrone abuse.
Article Synopsis
- Mephedrone is a popular drug that affects the brain by interacting with monoamine transporters, but its relationship with glutamate transmission was not well understood.
- Researchers conducted a study involving behavioral tests and advanced imaging techniques to explore how glutamate levels change in the brains of rats after mephedrone use.
- The findings revealed that mephedrone increases glutamate levels in the hippocampus and that the drug's rewarding effects can be reversed by memantine, suggesting a significant role of glutamatergic transmission in mephedrone's effects.
Fishing for a deeper understanding of nicotine effects using zebrafish behavioural models.
Olga Wronikowska Agnieszka Michalak Krystyna Skalicka-Woźniak Alexander D Crawford Barbara Budzyńska
Prog Neuropsychopharmacol Biol Psychiatry
March 2020
Nicotine, the primary psychoactive component of tobacco, is the most widely used drug of abuse. Although the substance is well-known, there is still a lack of information concerning its long-term neurological and physiological effects and its mechanisms of action. In order to search for new, effective drugs in the therapy of nicotinism, as well as to design new drugs that exert positive nicotine-like effects, further experiments are needed, ideally also using new behavioural models and paradigms.
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