Publications by authors named "Olga V Narvskaya"
Infect Genet Evol
October 2019
Article Synopsis
- Japan has a high incidence rate of nontuberculous mycobacterial lung disease, primarily caused by Mycobacterium avium subsp. hominissuis (MAH), with environmental sources like bathrooms suspected to be key infection points.
- A study analyzed samples from 180 residences and found a 16.1% detection rate of MAH, varying by region, with higher rates in Kanto and Kinki compared to much lower rates in other regions.
- Genetic analysis indicated that MAH from bathrooms showed significant genetic similarities to isolates from lung disease patients in Japan, reinforcing the idea that bathrooms are important potential sources of MAH infection.
Article Synopsis
- Tuberculosis (TB) is a global health issue, especially with rising drug-resistant strains and connections to HIV, yet there's a lack of a centralized resource linking TB genome data with geographic and clinical information.
- The Genome-wide Mycobacterium tuberculosis Variation (GMTV) database compiles genome variations from M. tuberculosis strains in Russia, featuring data on drug resistance, clinical outcomes, and more, accessible through an online browser.
- GMTV helps track changes in TB strains across different regions, supports research on drug resistance and clinical effects, and enhances comparisons of M. tuberculosis genomes.
Article Synopsis
- The study focuses on the Mycobacterium tuberculosis (MTB) Beijing family, specifically the B0/W148 group found in Russia, which is known for being widespread, hypervirulent, and drug-resistant.
- Researchers sequenced four clinical isolates from this group and compared their genomes to the W-148 strain to identify significant genomic features.
- They discovered two large genomic inversions in the B0/W148 strains, suggesting that such rearrangements in MTB are more common than previously thought, highlighting the need for further research into these genetic changes.
