Publications by authors named "Olga Romantsova"
Ewing sarcoma (ES) is one of the most frequent types of malignant tumors among children. The active metabolic state of ES cells presents a new potential target for therapeutic interventions. As a primary regulator of cellular homeostasis, carbonic anhydrases (CAs; EC 4.
View Article and Find Full Text PDFBackground: Ewing sarcoma (ES) cells exhibit extreme plasticity that contributes to the cell's survival and recurrence. Although multiple studies reveal various signaling pathways mediated by the EWSR1/FLI1 fusion, the specific transcriptional control of tumor cell resistance to doxorubicin is unknown. Understanding the molecular hubs that contribute to this behavior provides a new perspective on valuable therapeutic options against tumor cells.
View Article and Find Full Text PDFArticle Synopsis
- Ewing's sarcoma (ES) is a highly aggressive cancer primarily affecting teenagers, requiring a combination of surgery and systemic therapies for treatment.
- Many patients with ES develop drug resistance, which complicates their treatment and often leads to worsening disease.
- Recent research highlights the potential of targeting specific oncogenic drivers related to ES, providing new avenues for therapy and improving outcomes for patients.