F-Fluoroethyl-L Tyrosine Positron Emission Tomography Radiomics in the Differentiation of Treatment-Related Changes from Disease Progression in Patients with Glioblastoma.

The follow-up of glioma patients after therapeutic intervention remains a challenging topic, as therapy-related changes can emulate true progression in contrast-enhanced magnetic resonance imaging. F-fluoroethyl-tyrosine (F-FET) is a radiopharmaceutical that accumulates in glioma cells due to an increased expression of L-amino acid transporters and, contrary to gadolinium, does not depend on blood-brain barrier disruption to reach tumoral cells. It has demonstrated a high diagnostic value in the differentiation of tumoral viability and pseudoprogression or any other therapy-related changes, especially when combining traditional visual analysis with modern radiomics.

Seasonal peculiarities of PCDD/Fs levels in bank voles inhabiting sites in the vicinity of the landfill with municipal wastes (Moscow, Russia).

Differences in PCDD/Fs concentrations were registered among adult bank voles (Myodes glareolus) inhabiting forest in the vicinity of the Landfill Salariyevo (Moscow, Russia) and caught in early spring (over-winter survivors) and late summer. The levels of highly toxic congeners and WHO-TEQ in samples of wintering voles were much lower than those in samples got in summer. This difference was investigated analyzing PCDD/Fs in sexually matured animals and offspring obtained in vivarium.

Surface energy balance of the Sygyktinsky Glacier, south Eastern Siberia, during the ablation period and its sensitivity to meteorological fluctuations.

The physically based melt of the low elevation Eastern Siberian glaciers is poorly understood due to the lack of direct micrometeorological studies. We used an automatic meteorological station to record the meteorological and energy characteristics of the Sygyktinsky Glacier, south Eastern Siberia (56.8° N, 117.

Pregnancy Outcomes in Women After Arterial Switch Operation for Transposition of the Great Arteries: Results From ROPAC (Registry of Pregnancy and Cardiac Disease) of the European Society of Cardiology EURObservational Research Programme.

Background In the past 3 decades, the arterial switch procedure has replaced the atrial switch procedure as treatment of choice for transposition of the great arteries. Although survival is superior after the arterial switch procedure, data on pregnancy outcomes are scarce and transposition of the great arteries after arterial switch is not yet included in the modified World Health Organization classification of maternal cardiovascular risk. Methods and Results The ROPAC (Registry of Pregnancy and Cardiac disease) is an international prospective registry of pregnant women with cardiac disease, part of the European Society of Cardiology EURObservational Research Programme.

Amphiphilic Polypeptides for VEGF siRNA Delivery into Retinal Epithelial Cells.

Polyethyleneimine, poly-L-lysine, chitosan and some others cationic polymers have been thoroughly studied as nucleic acid delivery systems in gene therapy. However, the drug release from these systems proceeds at a very low rate due to extremely high binding between a carrier and gene material. To reduce these interactions and to enhance drug release, we developed a set of amphiphilic polypeptides containing positively and negatively charged amino acids as well as a hydrophobic one.