Oxidative stress induced by the Fe/ascorbic acid system or model ischemia in vitro: effect of carvedilol and pyridoindole antioxidant SMe1EC2 in young and adult rat brain tissue.

New effective strategies and new highly effective neuroprotective agents are being searched for the therapy of human stroke and cerebral ischemia. The compound SMe1EC2 is a new derivative of stobadine, with enhanced antioxidant properties compared to the maternal drug. Carvedilol, a non-selective beta-blocker, possesses besides its cardioprotective and vasculoprotective properties also an antioxidant effect.

Reduction of oxidative stress in adjuvant arthritis. Comparison of efficacy of two pyridoindoles: stobadine dipalmitate and SMe1.2HCl.

The aim of this study was to evaluate the therapeutic potential of oxidative stress (OS) reduction by using pyridoindole (PI) antioxidants in adjuvant arthritis (AA). The substances tested were stobadine dipalmitate (STB) and SMe1. AA was used as animal model.

Association between tissue gamma-glutamyl-transferase and clinical markers of adjuvant arthritis in Lewis rats.

Objectives: To assess glucomannan and pyridoindole derivatives for possible antioxidant therapy of rheumatoid arthritis (RA) by using the model of adjuvant arthritis (AA). We evaluated the association between clinical markers of the adjuvant arthritis model used - increase of hind paw volume (HPV), changes of body mass (CBM), and tissue gamma-glutamyl transferase (GGT) activity assessed in the spleen and the joint.

Methods: AA was induced in Lewis rats by a single intradermal injection of Mycobacterium butyricum.

Content of protein carbonyl groups in gerbil brain after reversible bilateral carotid occlusion: effect of 2,3-dihydromelatonin.

Objectives: To investigate whether a new derivative of melatonin, (2,3-dihydromelatonin (DHM), prevented the oxidative stress induced by ischemia /reperfusion (I/R) in the gerbil brain. To specify the effect on endogenous antioxidant activity and protein modification in the brain cortex, we evaluated the contents of glutathione (total GSx=GSH+GSSG) and protein carbonyl groups (PCG).

Methods: Brain ischemia (I) was induced by (12 min) bilateral carotid occlusion (BCAO) in adult male gerbils (60-70 g b wt.