Relationship between HbA1c, fructosamine and clinical assessment of glycemic control in dogs.

Background: Serum fructosamine is a routine test used for clinical monitoring of diabetes mellitus (DM) but the usefulness of HbA1c for this purpose has not been extensively studied.

Hypothesis: The study aimed to compare the ability of blood HbA1c and serum fructosamine tests to correctly classify DM control determined using a clinically-based assessment.

Animals: 28 client-owned dogs with naturally-occurring diabetes mellitus.

Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs.

[This corrects the article DOI: 10.1371/journal.pone.

The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs.

Serum hypertonicity may develop during diabetes mellitus due to hyperglycemia and other biochemical changes. Hypertonicity may produce detrimental cellular and systemic effects and has been identified as a serum marker for some clinical disorders. In non-diabetic dogs, the mean cell volume difference, a novel erythrocyte measure, is increased by serum hypertonicity.