Objectives: We aimed to determine whether the plasma profile of lactate dehydrogenase (LDH) isoenzymes is altered in patients with COVID-19, and whether this is attributable to a specific release of LDH-3, the main LDH isoenzyme expressed in lungs.
Design: We collected fresh plasma aliquots from 17 patients (LDH range, 281-822 U/L) and seven controls (LDH < 230 U/L). In-gel relative activity of the different LDH isoenzymes was determined by electrophoresis and densitometric analysis.