How common are ear, nose and throat disorders in children with Noonan syndrome and other RASopathies?

Introduction: Noonan syndrome and related conditions (RASopathies) are known to be associated with abnormalities in many organ systems. It is our impression that few otolaryngologists are familiar with the manifestations of these syndromes and we therefore reviewed our hospital's patient cohort to identify the prevalence of ear, nose and throat disorders in these children.

Methods: We cross-referenced various hospital department databases (otolaryngology, audiology, cardiology, haematology and genetics) to try to identify as many children with Noonan and other RASopathies as possible.

Predictors of clinically significant postprocedural hypotension after carotid endarterectomy and carotid angioplasty with stenting.

Objectives: Significant hypotension after carotid endarterectomy (CEA) and carotid angioplasty with stenting (CAS) has been correlated with adverse outcomes. The objective of this study was to determine risk factors that predict hypotension after patients undergo CEA and CAS.

Methods: The review included 1474 CEA patients and 157 CAS patients who underwent procedures from 2002 to 2008.