Study of Reproductive Toxicity of the Liposomal Photosensitizer Lipophthalocyan.

Objective: Study of embryotoxicity, teratogenicity and reproductive toxicity of the new drug Lipophtalocyan in rats.

Material And Methods: Studies were conducted on 210 non-inbred female rats and 105 non-inbred male rats. The drug was administered daily via i.

Preclinical Toxicity of Paclitaxel Biopolymer Formulation.

Background: Poly(hydroxyalkanoates) (PHA) have recently attracted increasing attention due to their biodegradability and high biocompatibility, which makes them suitable for the development of new prolong drug formulations.

Objective: A preclinical toxicology study of paclitaxel biopolymer formulation (PBF) (paclitaxel-loaded poly(3- hydroxybutyrate) (PHB) microparticles) was done in order to assess its safety and to forecast side and toxic effects in a clinical study on patients.

Method: PHB microparticles loaded with antitumor cytostatic drug PTX were obtained by spray-drying method using Nano Spray Dryer B-90.