Publications by authors named "Olga I Zolotareva"
Comorbid states of diseases significantly complicate diagnosis and treatment. Molecular mechanisms of comorbid states of asthma and hypertension are still poorly understood. Prioritization is a way for identifying genes involved in complex phenotypic traits.
View Article and Find Full Text PDFComorbidity, a co-incidence of several disorders in an individual, is a common phenomenon. Their development is governed by multiple factors, including genetic variation. The current study was set up to look at associations between isolated and comorbid diseases of bronchial asthma and hypertension, on one hand, and single nucleotide polymorphisms associated with regulation of gene expression (eQTL), on the other hand.
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- Hypertension and bronchial asthma significantly impact global health, affecting roughly 1 billion adults with hypertension and millions suffering from asthma, leading to hundreds of thousands of deaths each year.
- The study introduced a bioinformatics methodology to analyze the comorbidity of these two diseases by identifying candidate genes that could reveal molecular mechanisms and guide the discovery of new treatments.
- Gene network analysis showed overlapping genes and interactions between asthma and hypertension, with IL10, TLR4, and CAT identified as key genes for further exploration in understanding their comorbidity.
In vitro selection of antibodies from large repertoires of immunoglobulin (Ig) combining sites using combinatorial libraries is a powerful tool, with great potential for generating in vivo scavengers for toxins. However, addition of a maturation function is necessary to enable these selected antibodies to more closely mimic the full mammalian immune response. We approached this goal using quantum mechanics/molecular mechanics (QM/MM) calculations to achieve maturation in silico.
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