Nanoparticles of nucleotide-free analogue of vitamin B formed in protein nanocarriers and their neuroprotective activity in vivo.

Recently, we have described the first supermolecular nanoentities of vitamin B derivative, viz. monocyano form of heptabutyl cobyrinate, unique nanoparticles with strong noncovalent intermolecular interactions, emerging optical and catalytic properties. Their nearest analogue, heptamethyl cobyrinate (ACCby), exhibits bioactivity.

Comprehensive high resolution study of the SiH(M=28,29,30) tetradecad stretching bands: Appearance and applications of the isotopic substitution effect in molecules of spherical symmetry.

A set of new relations between different spectroscopic parameters of the high symmetry XY spherical top molecules is derived on the basis of the general isotopic substitution theory, and a comprehensive high accurate analysis of the five stretching bands (the bands ν+ν(F), 2ν(F), 2ν(E), 2ν(A), and 2ν(A); the three latter ones are forbidden in absorption) of the tetradecad of the SiH molecule is made. The high resolution spectra of SiH(M=28,29,30) in their natural abundance were recorded with a Bruker IFS125 HR Fourier transform infrared spectrometer at the Technische Universität Braunschweig, Germany with an optical resolution of 0.003 cm and theoretically analyzed (in this case, for the first time both for all five bands of the SiH and SiH species, and for 2ν(E), 2ν(A) bands of the SiH one).

Improved Theory of the Effective Dipole Moments and Absolute Line Strengths of the XY Asymmetric Top Molecules in the Doublet Electronic States.

A new effective dipole moment model for the XY (C2v-symmetry) molecule in a doublet electronic state is derived that includes (as special cases) all currently known models of effective dipole moments for such types of molecules, and allows us to take into account the influence of spin-rotation interactions on the effective dipole moment operator that were not considered in the preceding studies. Necessary for the analysis of absolute line strengths, the matrix elements of this dipole moment operator are derived. A comparison with the previous analog models is made and discussed.

Effective Dipole Moment Model for Axially Symmetric Molecules: Application to the Precise Study of Absolute Line Strengths of the Fundamental of CHCl.

The effective dipole moment model for molecules of axial C3v symmetry is derived on the basis of the symmetry properties of a molecule which, on the one hand, is of the same order of efficiency (but much simpler and clearer in applications) as the analogous models derived on the basis of the irreducible tensorial sets theory, and, on the other hand, mathematically more correct in comparison with concepts like the Herman-Walles function used in the models. As an application of the general results obtained, we discuss high-resolution infrared spectra of CH335Cl, recorded with the Zürich prototype ZP2001 (Bruker IFS125 HR) Fourier transform infrared spectrometer at a resolution of 0.001 cm-1 and analyzed in the region of 880-1190 cm-1 (ν6 bending fundamental centered at ν0 = 1018.

High resolution spectroscopy of asymmetric top molecules in nonsinglet electronic states: the ν fundamental of chlorine dioxide (OClO) free radical in the XB electronic ground state.

Highly resolved spectra of the OClO isotopologue of chlorine dioxide were recorded with a Bruker IFS 125HR Fourier transform infrared spectrometer in the region of the ν band. The analysis was made in the frame of the spin-rotational effective Hamiltonian (in A-reduction and I-representation) taking into account spin-rotational coupling operators up to the sixth order and the corresponding reduction of the Hamiltonian. The mathematical description of the ro-vibrational spectra was implemented to the specially created computer program ROVDES.

Prognostic Value of Characterizing Myocardial Tissue by Cardiac MRI with T1 Mapping in HFpEF Patients: A Systematic Review and Meta-Analysis.

Objectives: Our study aimed at conducting a systematic review and meta-analysis, with the objective of evaluating the prognostic value of T1 mapping techniques via cardiac magnetic resonance (CMR) in heart failure with preserved ejection fraction (HFpEF) patients. Materials and methods: The protocol was prospectively registered in the international prospective register of systematic reviews PROSPERO (registration number CRD42022300991). We searched PubMed, Google Scholar, and EMBASE for studies examining the prognostic value of characterizing myocardial tissue via CMR imaging with T1 mapping in HFpEF.

Lithium Ascorbate as a Promising Neuroprotector: Fundamental and Experimental Studies of an Organic Lithium Salt.

Given the observable toxicity of lithium carbonate, neuropharmacology requires effective and non-toxic lithium salts. In particular, these salts can be employed as neuroprotective agents since lithium ions demonstrate neuroprotective properties through inhibition of glycogen synthetase kinase-3β and other target proteins, increasing concentrations of endogenous neurotrofic factors. The results of theoretical and experimental studies of organic lithium salts presented here indicate their potential as neuroprotectors.

High resolution ro-vibrational analysis of molecules in doublet electronic states: the fundamental of chlorine dioxide (OClO) in the electronic ground state.

We report the spectrum of the ν1 fundamental of chlorine dioxide centered in the infrared atmospheric window at 945.592 cm-1 measured with essentially Doppler limited resolution at an instrumental line width of 0.001 cm-1 using the Zürich prototype ZP2001 Bruker IFS 125 HR Fourier transform infrared spectrometer.

Vitamin D deficiency in Kazakhstan: Cross-Sectional study.

Vitamin D deficiency (VDD) is one of the serious and highly debatable public health problems affecting at least one billion of world population. This study objected to evaluate Vitamin D status in adult population of both sexes residing in different geographical areas of Kazakhstan and to elucidate the possible contributing factors related to VDD. This cross-sectional study covered 6 regions of Kazakhstan and applied the systematic random sampling to recruit 1347 healthy adults (of whom 819 were females) with mean age 44 ± 14 years.

Encapsulation of vitamin B into nanoengineered capsules and soft matter nanosystems for targeted delivery.

Targeted delivery of vitamins to a desirable area is an active branch in a modern pharmacology. The most important and difficult delivery of vitamin B is that to bone marrow and nerve cells. Herein we present a first step towards the development of two types of smart carriers, polymer capsules and lyotropic liquid-crystalline nanosystems, for vitamin B targeted delivery and induced release.

On the method of precise abundance determination of isotopologues in a gas mixture.

A method is presented which allows one to derive partial pressures of isotopologue molecules in a gaseous mixture under the conditions of rapid isotope exchange. For this purpose, isotopic relations between effective dipole moment parameters of a "parent" molecule and its related isotopically substituted species are derived on the basis of the general isotopic substitution theory. The efficiency of the method is illustrated.

Deficit of Magnesium and States of Hypercoagulation: Intellectual Analysis of Data Obtained From a Sample of Patients Aged 18-50 years From Medical and Preventive Facilities in Russia.

Unlabelled: The states characterized by pronounced hypercoagulable components (deep vein thrombosis, cardio- and cerebro-vascular pathologies) are caused by multiple pathophysiological factors, including insufficient supply of magnesium (Mg) and other micronutrients.

Aim: to present results of analysis of the Institute of Microelements Data Base (IMDB) performed from point of view of interrelationships of Mg deficit and hypercoagulable states in adults treated in medico-preventive facilities of Central, Northwestern, Northern, and Siberian federal districts of Russia.

Methods: The analysis was realized as analysis of data obtained in a cross-sectional study.

Noninvasive Predictors of Malignant Arrhythmias.

Background: Prediction and potential prevention of sudden cardiac death (SCD) due to malignant ventricular arrhythmia (MVA) represent an obvious unmet medical need. We estimated the prognostic relevance of numerous biomarkers associated with future MVA development in patients with coronary artery disease (CAD) over 2 years of follow-up.

Methods: Patients with stable documented CAD (n = 97) with a mean age of 61 ± 10 years were prospectively enrolled in a single-center observational cohort study.

Effect of alvitili on immunological parameters in often ailing children.

The problem of the rehabilitation of often ailing children is not yet elucidated despite of a substantial amount of research done in this field. It is acknowledged that the impairment of immune reactivity is a pathogenetic foundation of often and prolonged respiratory diseases in children. In this connection, the aim of the study was to evaluate the effect of alvitili on the main immunologic parameters in children who get ill frequently.

Dual effect of cerebrolysin in children with attention deficit syndrome with hyperactivity: neuroprotection and immunomodulation.

Children with attention deficit syndrome with hyperactivity (ADSH) are characterised by attention and motor deficiencies and obvious immune disorders, which manifest as recurrent acute viral respiratory tract infections and changes in immunological parameters. It was established that the structure of deviations in the spectrum of elements in children with ADSH has characteristic features. The atomic emission analysis of cerebrolysin detected an advantageous combination of trace elements with neuroactive and antioxidant properties.

Immunoactive Properties of Cerebrolysin.

In children (aged 3-8 years old) with minimal cerebral dysfunction the immune status was studied before and after cerebrolysin administration in the dosage of 1 ml per 10 kg of child's weight, intramuscularly, within one month. The cerebrolysin administration resulted in an increase in the level of CD19(+) cells with a simultaneous normalization of serum IgG and IgA levels. The count of CD4(+) lymphocytes has risen.