Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes.

Objective: We studied the association between polymorphisms in the UCP genes and diabetes complications in patients with type 1 diabetes.

Research Design And Methods: We analyzed 227 patients with type 1 diabetes using PCR and subsequent cleavage by restriction endonucleases for the promoter variants A-3826G in the UCP1 gene, G-866A in the UCP2 gene, and C-55T in the UCP3 gene.

Results: No effect of the A-3826G polymorphism in the UCP1 gene on diabetes complications was found.