Publications by authors named "Olga E Talantova"
We report on the case of prenatal detection of trisomy 2 in placental biopsy and further algorithm of genetic counseling and testing. A 29-year-old woman with first-trimester biochemical markers refused chorionic villus sampling and preferred targeted non-invasive prenatal testing (NIPT), which showed low risk for aneuploidies 13, 18, 21, and X. A series of ultrasound examinations revealed increased chorion thickness at 13/14 weeks of gestation and fetal growth retardation, a hyperechoic bowel, challenging visualization of the kidneys, dolichocephaly, ventriculomegaly, increase in placental thickness, and pronounced oligohydramnios at 16/17 weeks of gestation.
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- The study explores telomere length (TL) in chorionic cytotrophoblast cells from both normal and abnormal first trimester pregnancies, finding no significant differences in TL for karyotypically normal samples between miscarriages and ongoing pregnancies.
- Notably, karyotypically abnormal samples showed significantly higher TLs in ongoing pregnancies compared to miscarriages, and also had higher TLs compared to karyotypically normal samples in ongoing pregnancies.
- The research suggests that interchromatid TL asymmetry and its association with certain methylation patterns are related to the developmental processes of chorionic cytotrophoblast, indicating that TL variations are inherited rather than influenced by telomere elongation mechanisms.
Age and Serum AMH and FSH Levels as Predictors of the Number of Oocytes Retrieved from Chromosomal Translocation Carriers after Controlled Ovarian Hyperstimulation: Applicability and Limitations.
Genes (Basel)
December 2020
We studied the impact of age and the serum anti-Müllerian hormone (AMH)/follicle-stimulating hormone (FSH) levels on the number of cumulus-oocyte complexes (COCs) retrieved from female reciprocal and Robertsonian translocation carriers after controlled ovarian hyperstimulation (COH). The number of COCs retrieved after COH was retrospectively analyzed in female translocation carriers and 46,XX partners of male translocation carriers from 100 couples. The median number of COCs varied from nine to 16 and did not differ among subgroups of women categorized by age, presence and type of a translocation.
View Article and Find Full Text PDFWe report on the phenotype and the reproductive history of an adult female patient with an unbalanced karyotype: 8p23 and 18p11.3 terminal deletions and 8p22 duplication. The indication for karyotyping of the 28-year-old patient was a structural rearrangement in her miscarriage specimen: 45,ХХ,der(8;18)t(8;18)(p23;p11.
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- 5-hydroxymethylcytosine (5hmC) is a modified form of 5-methylcytosine (5mC) and exhibits significant variations between DNA strands and cells in mammals.* -
- Research revealed different patterns of 5hmC distribution in noncultured human cells, observing three types of chromosomes based on 5hmC accumulation: hydroxymethylated, hemihydroxymethylated, and nonhydroxymethylated.* -
- Unlike the variable 5hmC distribution, the locations of 5mC were consistent across chromosomes, indicating a stable methylation pattern particularly in certain heterochromatic regions of embryonic lung cells.*