Enhancement of laryngeal contrasts in non-native English clear speech: a comparison between L2-immersed sequential bilinguals and L1-immersed speakers.

Clear speech, a speaking style used to mitigate communicative circumstances affecting the transmission or decoding of speech signal, often involves the enhancement of language-specific phonological contrasts, including laryngeal contrasts. This study investigates the role of language dominance in the implementation of language-specific laryngeal contrasts in L2 clear speech. Two groups of Korean-English speakers (L1 Korean) were tested: a relatively less Korean-dominant L2-immersed group of sequential bilinguals ( = 30) and a strongly Korean-dominant L1-immersed group ( = 30), with dominance assessed based on the results of the Bilingual Language Profile.

Non-native talkers and listeners and the perceptual benefits of clear speech.

This study examined the intelligibility benefit of native and non-native clear speech for native and non-native listeners when the first language background of non-native talkers and listeners is matched. All four combinations of talkers and listeners were tested: native talker-native listener, non-native talker-native listener, native talker-non-native listener, and non-native talker-non-native listener. Listeners were presented with structurally simple but semantically anomalous English sentences produced clearly or casually and mixed with speech-shaped noise at 0 dB signal-to-noise ratio and asked to write down what they heard.

The effect of allophonic variability on L2 contrast perception: Evidence from perception of English vowels.

Current frameworks of L2 phonetic acquisition remain largely underspecified with respect to the role of L1 allophonic variability in acquisition. Examining the role of L1 allophonic variability, the current study compared the perceptual discrimination of English /i-ɪ/ and /ɛ-æ/ by L1 Korean and L1 Mandarin speakers. Korean and Mandarin vowel inventories differ in that Mandarin employs significantly greater allophonic variation of the mid-region /E/ vowel.

More Is Not Always Better: Local Models Provide Accurate Predictions of Spectral Properties of Porphyrins.

The development of new functional materials based on porphyrins requires fast and accurate prediction of their spectral properties. The available models in the literature for absorption wavelength and extinction coefficient of the Soret band have low accuracy for this class of compounds. We collected spectral data for porphyrins to extend the literature set and compared the performance of global and local models for their modelling using different machine learning methods.

Molecular Recognition of Imidazole Derivatives by Co(III)-Porphyrinsin Phosphate Buffer (pH = 7.4) and Cetylpyridinium Chloride Containing Solutions.

Bymeans of spectrophotometric titration and NMR spectroscopy, the selective binding ability ofthe Co(III)-5,15-bis-(3-hydroxyphenyl)-10,20-bis-(4-sulfophenyl)porphyrin (Со(III)Р1) andCo(III)-5,15-bis-(2-hydroxyphenyl)-10,20-bis-(4-sulfophenyl)porphyrin (Со(III)Р2) towards imidazole derivatives of various nature (imidazole (L1), metronidazole (L2), and histamine (L3)) in phosphate buffer (pH 7.4) has been studied. It was found that in the case of L2, L3 the binding of the "first" ligand molecule by porphyrinatesCo(III)P1 and Co(III)P2 occurs with the formation of complexes with two binding sites (donor-acceptor bond at the center and hydrogen bond at the periphery of the macrocycle), while the "second" ligand molecule is added to the metalloporphyrin only due to the formation of the donor-acceptor bond at the macrocycle coordination center.

Correction to: Spectral-Fluorescence Properties of Zn(II)-Octaphenyltetraazaporphyrins.

The original version of this article unfortunately contained a mistake. In the section of 'Acknowledgements' the grant number is incorrectly indicated. The corrected grant number is given below.

Spectral-Fluorescence Properties of Zn(II)-Octaphenyltetraazaporphyrins.

Zn(II)-octa-(4-chlorophenyl)- and Zn(II)-octa-(4-bromophenyl)tetraazaporphyrins were synthesized by the reaction of cyclotetramerization of di-(4-chlorophenyl)- and di-(4-bromophenyl)maleonitriles with zinc(II) chloride. The obtained compounds were identified by UV-vis, IR, NMR H spectroscopy and mass spectrometry. Geometry optimization of the series of halogenated Zn(II)-octaaryltetraazaporphyrins was performed using the density functional method with the BP86 functional and the def2-TZVP basis set.

Vowel-to-Vowel Coarticulation in Spanish Nonwords.

The present study examined vowel-to-vowel (VV) coarticulation in backness affecting mid vowels /e/ and /o/ in 36 Spanish nonwords produced by 20 native speakers of Spanish, aged 19-50 years (mean = 30.7; SD = 8.2).

Acoustic Correlates of the Four-Way Laryngeal Contrast in Marathi.

The study examines acoustic correlates of the four-way laryngeal contrast in Marathi, focusing on temporal parameters, voice quality, and onset f0. Acoustic correlates of the laryngeal contrast were investigated in the speech of 33 native speakers of Marathi, recorded in Mumbai, India, producing a word list containing six sets of words minimally contrastive in terms of laryngeal specification of word-initial velar stops. Measurements were made for the duration of prevoicing, release, and voicing during release.

The Role of Perception in the Typology of Geminate Consonants: Effects of Manner of Articulation, Segmental Environment, Position, and Stress.

The present study seeks to answer the question of whether consonant duration is perceived differently across consonants of different manners of articulation and in different contextual environments and whether such differences may be related to the typology of geminates. The results of the cross-linguistic identification experiment suggest higher perceptual acuity in labeling short and long consonants in sonorants than in obstruents. Duration categories were also more consistently and clearly labeled in the intervocalic than in the preconsonantal environment, in the word-initial than in the word-final position, and after stressed vowels than between unstressed vowels.

Evidence for cooperative Na and Cl binding by strongly hydrated l-proline.

In nature the amino acid l-proline (Pro) is a ubiquitous and highly effective osmolyte protecting cells against osmotic stress. To understand this effect knowledge of the hydration of Pro and its interactions with dissolved salts is essential. We studied these properties by combining statistical mechanics and broadband dielectric spectroscopy and found that Pro remains strongly hydrated up to high amino-acid concentrations.

Proline hydration at low temperatures: its role in the protection of cell from freeze-induced stress.

The natural amino acid L-α-proline (Pro) is a compatible osmolyte which accumulates in the cell cytoplasm to protect structure and function of various proteins and enzymes under abiotic stress, like for instance, freezing. It is assumed that the interactions of Pro with intracellular water play an important role in the protection mechanism. However, until now the details of these interactions are far from being fully understood.

Ion-selective interactions of biologically relevant inorganic ions with alanine zwitterion: a 3D-RISM study.

The ion-molecular association between inorganic ions and the charged groups of alanine zwitterion in biologically relevant aqueous salt solutions, namely NaCl(aq), KCl(aq), MgCl2(aq), and CaCl2(aq), has been investigated over a wide range of electrolyte concentration. The influence of salt concentration on the stability of the formed ion-molecular associates is analyzed. The structure of the formed aggregates and its dependence on salt concentration and chemical nature of the inorganic ion are discussed.

Development of a questionnaire to evaluate practitioners' confidence and knowledge in primary care in managing chronic kidney disease.

Background: In the UK, chronic disease, including chronic kidney disease (CKD) is largely managed in primary care. We developed a tool to assess practitioner confidence and knowledge in managing CKD compared to other chronic diseases. This questionnaire was part of a cluster randomised quality improvement interventions in chronic kidney disease (QICKD; ISRCTN56023731).

Auditory enhancement and second language experience in Spanish and English weighting of secondary voicing cues.

The role of secondary cues in voicing categorization was investigated in three listener groups: Monolingual English (n = 20) and Spanish speakers (n = 20), and Spanish speakers with significant English experience (n = 16). Results showed that, in all three groups, participants used onset f0 in making voicing decisions only in the positive voice onset time (VOT) range (short lag and long lag tokens), while there was no effect of onset f0 on voicing categorization within the negative VOT range (voicing lead tokens) for any of the participant groups. These results support an auditory enhancement view of perceptual cue weighting: Onset f0 serves as a secondary cue to voicing only in the positive VOT range where it is not overshadowed by the presence of pre-voicing.

Audit-based education lowers systolic blood pressure in chronic kidney disease: the Quality Improvement in CKD (QICKD) trial results.

Strict control of systolic blood pressure is known to slow progression of chronic kidney disease (CKD). Here we compared audit-based education (ABE) to guidelines and prompts or usual practice in lowering systolic blood pressure in people with CKD. This 2-year cluster randomized trial included 93 volunteer general practices randomized into three arms with 30 ABE practices, 32 with guidelines and prompts, and 31 usual practices.

Consistent data recording across a health system and web-enablement allow service quality comparisons: online data for commissioning dermatology services.

A new distributed model of health care management is being introduced in England. Family practitioners have new responsibilities for the management of health care budgets and commissioning of services. There are national datasets available about health care providers and the geographical areas they serve.

Confidence and quality in managing CKD compared with other cardiovascular diseases and diabetes mellitus: a linked study of questionnaire and routine primary care data.

Background: Much of chronic disease is managed in primary care and chronic kidney disease (CKD) is a recent addition. We are conducting a cluster randomised study of quality improvement interventions in CKD (QICKD) - Clinical Trials Registration: ISRCTN56023731. CKD registers have a lower than expected prevalence and an initial focus group study suggested variable levels of confidence in managing CKD.

Quality achievement and disease prevalence in primary care predicts regional variation in renal replacement therapy (RRT) incidence: an ecological study.

Background: Diabetes Meillitus (DM) and hypertension (HT) are important causes of end-stage renal disease (ESRD) and renal replacement therapy (RRT) is the standard active treatment. Financially, incentivized quality initiatives for primary care include pay-for-performance (P4P) in DM and HT. Our aim was to examine any effect of disease prevalence and P4P on RRT incidence and regional variation.

Correlation between cytogenetic abnormalities in cells and metabolic shifts in children with spinal deformities.

We studied the relationship between cytogenetic abnormalities in buccal epithelial cells and metabolic shifts in children with scoliosis and kyphosis. The incidence of nucleus abnormalities and the corresponding metabolic shifts were found to depend on the presence of spinal deformities and ecological factors. The problem of formation of risk groups for spinal deformities in ecologically unfavorable regions is discussed.

Consequences for the teenagers after anogenital sexual contacts.

Necessity of research of teenagers after violent actions of sexual character is connected basically with anogenital sexual contacts. Survey of victims by the medicolegal (forensics medicines) expert assumes knowledge of illnesses like anorectal complex, causing anorectal dysfunctions (perianal itch, proctalgia, a crack of anal tract, encopresis). All specified diseases concerned with anorectal rings can be idiopatic (without the established reason) and secondary (locks, violent actions of sexual character, medical manipulations, traumas).

Morphological changes in genesial system of men: medico-legal aspects.

With the purpose of perfection of examination the character of structural changes in testicles and prostate is investigated; the comparative qualitative and quantitative analysis of cellular reactions of persons with chronic somatopathies (rheumatic disease, idiopathic hypertensia) and chronic household intoxications (alcoholic illness, narcomania) is carried out. The work is carried out on 50 corpses of male persons, 18-35 years old, who died of chronic drunkenness (13 observations), narcomania (20), idiopathic hypertensia (9), and rheumatic disease (8). The suppression of testicles was characterized by disturbances of spermatogenesis at a level of the cell population, characteristic for a zero and first degree of spermatogenesis activity especially expressed in chronic narcotic intoxication.